Orioles Roster & Staff
Transactions
| Date | Transaction |
| 05/31/22 | Baltimore Orioles recalled LHP Zac Lowther from Norfolk Tides. |
| 05/31/22 | Baltimore Orioles optioned RHP Cody Sedlock to Norfolk Tides. |
| 05/29/22 | Baltimore Orioles optioned RHP Denyi Reyes to Norfolk Tides. |
| 05/28/22 | Baltimore Orioles designated CF Jahmai Jones for assignment. |
| 05/28/22 | Baltimore Orioles optioned RHP Beau Sulser to Norfolk Tides. |
| 05/28/22 | Baltimore Orioles recalled RHP Denyi Reyes from Norfolk Tides. |
| 05/28/22 | Baltimore Orioles selected the contract of RHP Cody Sedlock from Norfolk Tides. |
| 05/27/22 | Baltimore Orioles sent C Anthony Bemboom outright to Norfolk Tides. |
| 05/25/22 | Baltimore Orioles transferred LHP Alexander Wells from the 10-day injured list to the 60-day injured list. Left elbow inflammation. |
| 05/25/22 | Baltimore Orioles signed free agent RHP Nick Richmond to a minor league contract. |
| 05/25/22 | Baltimore Orioles transferred LHP Alexander Wells from the 10-day injured list to the 60-day injured list. Left elbow inflammation. |
| 05/25/22 | Baltimore Orioles signed free agent Anthony Bello to a minor league contract. |
| 05/25/22 | Baltimore Orioles optioned RHP Chris Vallimont to Bowie Baysox. |
| 05/25/22 | Baltimore Orioles claimed RHP Chris Vallimont off waivers from Minnesota Twins. |
| 05/24/22 | Baltimore Orioles sent RHP Dean Kremer on a rehab assignment to Norfolk Tides. |
| 05/23/22 | Baltimore Orioles optioned RHP Mike Baumann to Norfolk Tides. |
| 05/23/22 | Baltimore Orioles recalled RHP Logan Gillaspie from Norfolk Tides. |
| 05/23/22 | Baltimore Orioles recalled RHP Marcos Diplan from Norfolk Tides. |
| 05/23/22 | Baltimore Orioles optioned 3B Tyler Nevin to Norfolk Tides. |
| 05/23/22 | Baltimore Orioles recalled RHP Beau Sulser from Norfolk Tides. |
| 05/21/22 | Baltimore Orioles designated C Anthony Bemboom for assignment. |
| 05/21/22 | Baltimore Orioles activated 1B Ryan Mountcastle from the 10-day injured list. |
| 05/21/22 | Baltimore Orioles optioned RHP Logan Gillaspie to Norfolk Tides. |
| 05/21/22 | Baltimore Orioles optioned LHP Nick Vespi to Norfolk Tides. |
| 05/21/22 | Baltimore Orioles recalled RHP Mike Baumann from Norfolk Tides. |
| 05/21/22 | Baltimore Orioles selected the contract of C Adley Rutschman, and from Norfolk Tides. |
| 05/20/22 | Baltimore Orioles placed RHP Travis Lakins Sr. on the 15-day injured list retroactive to May 12, 2022. |
| 05/20/22 | Baltimore Orioles sent LHP Logan Allen outright to Norfolk Tides. |
| 05/18/22 | Baltimore Orioles sent RHP Dean Kremer on a rehab assignment to Bowie Baysox. |
| 05/18/22 | Baltimore Orioles traded LHP Paul Fry to Arizona Diamondbacks for RHP Luis Osorio. |
| 05/18/22 | Baltimore Orioles traded LHP Paul Fry to Arizona Diamondbacks for RHP Luis Osorio. |
| 05/17/22 | Baltimore Orioles designated LHP Logan Allen for assignment. |
| 05/17/22 | Baltimore Orioles recalled RHP Logan Gillaspie from Norfolk Tides. |
| 05/17/22 | Baltimore Orioles selected the contract of LHP Nick Vespi from Norfolk Tides. |
| 05/17/22 | Baltimore Orioles optioned 3B Rylan Bannon to Norfolk Tides. |
| 05/14/22 | Baltimore Orioles designated LHP Paul Fry for assignment. |
| 05/14/22 | Baltimore Orioles recalled CF Ryan McKenna, , , , and from Norfolk Tides. |
| 05/14/22 | Baltimore Orioles claimed RHP Beau Sulser off waivers from Pittsburgh Pirates. |
| 05/14/22 | Baltimore Orioles optioned RHP Denyi Reyes to Norfolk Tides. |
| 05/13/22 | Baltimore Orioles activated RHP Jorge Lopez from the bereavement list. |
| 05/13/22 | Baltimore Orioles placed 1B Ryan Mountcastle on the 10-day injured list retroactive to May 11, 2022. Left wrist forearm strain. |
| 05/12/22 | Baltimore Orioles signed free agent LHP Jose Leandro to a minor league contract. |
| 05/12/22 | Baltimore Orioles optioned LHP Paul Fry to Norfolk Tides. |
| 05/12/22 | Baltimore Orioles selected the contract of RHP Denyi Reyes from Norfolk Tides. |
| 05/12/22 | Baltimore Orioles recalled 3B Rylan Bannon from Norfolk Tides. |
| 05/10/22 | Baltimore Orioles signed free agent RHP Hector Perez to a minor league contract. |
| 05/10/22 | Baltimore Orioles placed RHP Jorge Lopez on the bereavement list. |
| 05/10/22 | Baltimore Orioles recalled RHP Travis Lakins Sr. from Norfolk Tides. |
| 05/09/22 | Baltimore Orioles optioned RHP Travis Lakins Sr. to Norfolk Tides. |
| 05/08/22 | Baltimore Orioles recalled RHP Travis Lakins Sr. from Norfolk Tides. |
| 05/06/22 | Baltimore Orioles activated LHP Logan Allen. |
| 05/06/22 | Baltimore Orioles sent 3B Kelvin Gutierrez outright to Norfolk Tides. |
| 05/06/22 | Baltimore Orioles optioned RHP Travis Lakins Sr. to Norfolk Tides. |
| 05/05/22 | Baltimore Orioles signed free agent RHP Yeiber Cartaya to a minor league contract. |
| 05/05/22 | Baltimore Orioles claimed LHP Logan Allen off waivers from Cleveland Guardians. |
| 05/02/22 | Baltimore Orioles designated 3B Kelvin Gutierrez for assignment. |
| 05/02/22 | Baltimore Orioles optioned CF Ryan McKenna to Norfolk Tides. |