Orioles Roster & Staff
Transactions
| Date | Transaction |
| 11/30/21 | Baltimore Orioles activated 2B Rougned Odor. |
| 11/30/21 | Baltimore Orioles signed free agent 2B Rougned Odor. |
| 11/30/21 | Baltimore Orioles activated 2B Rougned Odor. |
| 11/30/21 | Washington Nationals claimed SS Lucius Fox off waivers from Baltimore Orioles. |
| 11/30/21 | Baltimore Orioles sent SS Richie Martin outright to Norfolk Tides. |
| 11/29/21 | Baltimore Orioles signed free agent RHP Denyi Reyes to a minor league contract. |
| 11/29/21 | Baltimore Orioles released RHP Brooks Kriske. |
| 11/24/21 | Baltimore Orioles activated LHP Cionel Perez. |
| 11/24/21 | Baltimore Orioles activated LHP Cionel Pérez. |
| 11/24/21 | Baltimore Orioles claimed LHP Cionel Perez off waivers from Cincinnati Reds. |
| 11/19/21 | Baltimore Orioles activated RHP Felix Bautista. |
| 11/19/21 | Baltimore Orioles signed free agent RHP Marcos Diplan to a minor league contract. |
| 11/19/21 | Baltimore Orioles activated RHP Felix Bautista. |
| 11/19/21 | Baltimore Orioles selected the contract of SS Terrin Vavra from Bowie Baysox. |
| 11/19/21 | Baltimore Orioles selected the contract of RHP Felix Bautista from Norfolk Tides. |
| 11/19/21 | Baltimore Orioles selected the contract of RHP Logan Gillaspie from Bowie Baysox. |
| 11/19/21 | Baltimore Orioles selected the contract of RHP Kyle Bradish from Norfolk Tides. |
| 11/19/21 | Baltimore Orioles selected the contract of LHP D.L. Hall from Bowie Baysox. |
| 11/19/21 | Baltimore Orioles selected the contract of LHP Kevin Smith from Norfolk Tides. |
| 11/19/21 | Baltimore Orioles claimed SS Lucius Fox off waivers from Kansas City Royals. |
| 11/12/21 | Baltimore Orioles signed free agent RHP Spenser Watkins to a minor league contract. |
| 11/12/21 | Baltimore Orioles signed free agent RHP Rico Garcia to a minor league contract. |
| 11/08/21 | Baltimore Orioles claimed RHP Bryan Baker off waivers from Toronto Blue Jays. |
| 11/07/21 | Baltimore Orioles activated RHP Jorge Lopez from the 60-day injured list. |
| 11/07/21 | Baltimore Orioles activated SS Jorge Mateo from the 60-day injured list. |
| 11/07/21 | Baltimore Orioles activated LF DJ Stewart from the 60-day injured list. |
| 11/07/21 | Baltimore Orioles activated LHP Keegan Akin from the 60-day injured list. |
| 11/05/21 | San Francisco Giants claimed RHP Hunter Harvey off waivers from Baltimore Orioles. |
| 11/05/21 | Baltimore Orioles sent RHP Chris Ellis outright to Norfolk Tides. |
| 11/05/21 | Baltimore Orioles sent C Nick Ciuffo outright to Norfolk Tides. |
| 11/05/21 | Baltimore Orioles sent RHP Spenser Watkins outright to Norfolk Tides. |
| 11/03/21 | LHP Fernando Abad elected free agency. |
| 11/03/21 | Baltimore Orioles sent RHP Marcos Diplan outright to Norfolk Tides. |
| 11/03/21 | Baltimore Orioles sent C Pedro Severino outright to Norfolk Tides. |
| 11/03/21 | Baltimore Orioles sent RHP Conner Greene outright to Norfolk Tides. |
| 11/03/21 | RHP Matt Harvey elected free agency. |
| 11/03/21 | Pittsburgh Pirates claimed RHP Eric Hanhold off waivers from Baltimore Orioles. |