BOSTON -- When Ty Blach walked off the Fenway Park mound in the sixth inning, the Orioles looked on the path of winning their first round game since March 31 and Blach had put himself in position to earn his first victory since July 9, 2018.

The Red Sox had runners on first and third, but the Orioles already had recorded one out and built a cushion of run support with six runs in the first three innings.

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Making it through the sixth inning unscathed was key for the Orioles. They entered the game 32-3 this season when leading after six, while the Red Sox were 3-47 when trailing after the frame.

But the sixth quickly got out of hand in what spiraled into a lopsided 13-7 Orioles loss.

“[It] just didn’t go well that inning,” Orioles manager Brandon Hyde said. “Everything bad that could’ve happened, happened for us. It’s unfortunate.”

Gabriel Ynoa relieved Blach and was on the mound for all of one batter. He gave up a double to Christian Vazquez, which plated a run. That was it for the righty, who was replaced by left-hander Paul Fry.

The problem for the Orioles as they tried to get out of the inning was, the Red Sox were just getting started with their comeback. A pop up fly ball by Mitch Moreland landed between three converging Orioles, and Jonathan Villar’s erroneous throw to home allowed the tying run to score.

“When it went up, I was like, ‘Well, I don’t know what’s going to happen. Probably out,’” Moreland said. “I wasn’t very happy with myself. Then I was like, ‘Well, they shifted so much that it might fall,’ you know? And then it was coming down quick and when it hit the ground I was like, ‘I’ll take it. It works.’ Then it kind of snowballed right there.”

The Orioles recorded the second out of the sixth with a strikeout, but surrendered three more runs before ending the inning in a 9-6 hole.

“[Fry] came in and he got a pop up and punchout. We didn’t catch the pop up, and then the wheels fell off following the punchout of [Chris] Owings,” Hyde said. “Should’ve been out of there with a two-run lead. Unfortunately, it steamrolled on us.”

That same inning, Chance Sisco was injured not once, but twice. He fell to the ground after Sam Travis made contact in his shoulder-neck area crossing home, and left the game after being struck in the groin area by Xander Bogaerts’ foul ball. Sisco was being evaluated by the Orioles following the game.

Once the Orioles surrendered their lead, they never got it back. The Red Sox continued to pour on the runs with a total of six in the sixth inning, bringing 12 batters to the plate. The six runs allowed in the sixth inning were even more magnified because they erased a strong start to the game. Renato Nunez put the Orioles on the board with a three-run homer in the first inning, while Blach recorded six strikeouts (his most since July 23, 2017) over 5 1/3 innings.

“We did a great job early on getting on [Red Sox starter Nathan] Eovaldi and getting in their bullpen and scoring some runs,” Chris Davis said. “Ty threw the ball outstanding today and really deserved the win. But we made too many mistakes. When you make mistakes like that against a team like this, they’re going to make it hurt.”

The Orioles were on the losing end of the Red Sox’s largest comeback of 2019. They dropped to 5-11 on the season against the defending World Series champions, with one series remaining against them from Sept. 27-29, the last weekend of the regular season. The Orioles were swept for the 11th time this year.

“We’ve got to stay together,” Davis said. “I think that’s the biggest thing for us on and off the field. The lack of communication, making the mistakes that we made today, we can’t afford to do that. We’ve got to start pulling for one another, we’ve got to stay in it together, and we’ve got to keep going.”