Twins Roster & Staff
Transactions
| Date | Transaction |
| 06/29/22 | Minnesota Twins optioned RHP Josh Winder to St. Paul Saints. |
| 06/28/22 | Minnesota Twins activated SS Jorge Polanco from the 10-day injured list. |
| 06/28/22 | Minnesota Twins recalled RHP Josh Winder from St. Paul Saints. |
| 06/28/22 | Minnesota Twins optioned OF Mark Contreras to St. Paul Saints. |
| 06/26/22 | Minnesota Twins placed RHP Joe Smith on the 15-day injured list retroactive to June 24, 2022. Upper trap tightness. |
| 06/26/22 | Minnesota Twins recalled LHP Jovani Moran from St. Paul Saints. |
| 06/25/22 | Minnesota Twins placed OF Trevor Larnach on the 10-day injured list retroactive to June 24, 2022. Core muscle strain. |
| 06/25/22 | Minnesota Twins recalled OF Mark Contreras from St. Paul Saints. |
| 06/23/22 | Minnesota Twins optioned RHP Josh Winder to St. Paul Saints. |
| 06/19/22 | Minnesota Twins activated RF Kyle Garlick. |
| 06/19/22 | Minnesota Twins placed RHP Trevor Megill on the 15-day injured list retroactive to June 16, 2022. Right shoulder impingement. |
| 06/18/22 | Minnesota Twins signed free agent CF Braden Bishop to a minor league contract. |
| 06/17/22 | Minnesota Twins placed RF Alex Kirilloff on the 10-day injured list. Right wrist contusion. |
| 06/17/22 | Minnesota Twins recalled RF Alex Kirilloff from St. Paul Saints. |
| 06/16/22 | Minnesota Twins placed SS Jorge Polanco on the 10-day injured list retroactive to June 13, 2022. Low back tightness. |
| 06/16/22 | Minnesota Twins sent SS Elliot Soto outright to St. Paul Saints. |
| 06/15/22 | Minnesota Twins activated RHP Sonny Gray from the 15-day injured list. |
| 06/15/22 | Minnesota Twins sent RF Kyle Garlick on a rehab assignment to St. Paul Saints. |
| 06/15/22 | Minnesota Twins optioned LHP Jovani Moran to St. Paul Saints. |
| 06/14/22 | Minnesota Twins designated SS Elliot Soto for assignment. |
| 06/14/22 | Minnesota Twins activated RHP Joe Ryan. |
| 06/14/22 | Minnesota Twins activated RHP Joe Ryan. |
| 06/14/22 | Milwaukee Brewers claimed RHP Chi Chi Gonzalez off waivers from Minnesota Twins. |
| 06/13/22 | Minnesota Twins transferred RHP Cody Stashak from the 15-day injured list to the 60-day injured list. Right shoulder impingement. |
| 06/13/22 | Minnesota Twins optioned RHP Cole Sands to St. Paul Saints. |
| 06/13/22 | Minnesota Twins selected the contract of SS Elliot Soto from St. Paul Saints. |
| 06/13/22 | Minnesota Twins optioned RHP Cole Sands to St. Paul Saints. |
| 06/12/22 | Minnesota Twins designated RHP Chi Chi Gonzalez for assignment. |
| 06/12/22 | Minnesota Twins selected the contract of RHP Tyler Thornburg from St. Paul Saints. |
| 06/11/22 | Minnesota Twins transferred SS Royce Lewis from the 10-day injured list to the 60-day injured list. Right knee bone bruise. |
| 06/11/22 | Minnesota Twins optioned RHP Yennier Cano to St. Paul Saints. |
| 06/11/22 | Minnesota Twins selected the contract of RHP Chi Chi Gonzalez from St. Paul Saints. |
| 06/10/22 | Minnesota Twins signed free agent CF Zach Huffins to a minor league contract. |
| 06/10/22 | Minnesota Twins sent RHP Juan Minaya outright to St. Paul Saints. |
| 06/09/22 | Minnesota Twins signed free agent RHP Jose Brito to a minor league contract. |
| 06/09/22 | Minnesota Twins sent RHP Joe Ryan on a rehab assignment to St. Paul Saints. |
| 06/09/22 | Minnesota Twins sent RHP Josh Winder on a rehab assignment to St. Paul Saints. |
| 06/08/22 | Minnesota Twins activated SS Carlos Correa from the 10-day injured list. |
| 06/08/22 | Minnesota Twins designated RHP Juan Minaya for assignment. |
| 06/08/22 | Minnesota Twins selected the contract of RHP Jharel Cotton from St. Paul Saints. |
| 06/08/22 | Minnesota Twins optioned SS Jermaine Palacios to St. Paul Saints. |
| 06/07/22 | Minnesota Twins placed RF Kyle Garlick on the 10-day injured list retroactive to June 4, 2022. Left hamstring strain. |
| 06/07/22 | Minnesota Twins recalled RHP Cole Sands from St. Paul Saints. |
| 06/06/22 | Minnesota Twins signed free agent RHP Aaron Sanchez to a minor league contract. |
| 06/06/22 | Minnesota Twins signed free agent RHP Pierce Banks to a minor league contract. |
| 06/06/22 | Minnesota Twins placed RF Max Kepler on the 10-day injured list. Right fifth toe fracture. |
| 06/06/22 | Minnesota Twins activated RHP Trevor Megill from the restricted list. |
| 06/06/22 | Minnesota Twins placed RHP Bailey Ober on the 15-day injured list retroactive to June 2, 2022. Right groin strain. |
| 06/06/22 | Minnesota Twins activated RHP Emilio Pagan from the restricted list. |
| 06/06/22 | Minnesota Twins activated RF Max Kepler from the restricted list. |
| 06/06/22 | Minnesota Twins activated LHP Caleb Thielbar from the restricted list. |
| 06/06/22 | RHP Jharel Cotton returned to St. Paul Saints from Minnesota Twins. |
| 06/06/22 | RHP Ian Hamilton returned to St. Paul Saints from Minnesota Twins. |
| 06/06/22 | Minnesota Twins optioned OF Mark Contreras to St. Paul Saints. |
| 06/04/22 | Minnesota Twins activated CF Gilberto Celestino from the 10-day injured list. |
| 06/04/22 | RHP Chi Chi Gonzalez returned to St. Paul Saints from Minnesota Twins. |
| 06/03/22 | Minnesota Twins signed free agent RHP Tyler Thornburg to a minor league contract. |
| 06/03/22 | Minnesota Twins placed RHP Emilio Pagan on the restricted list. |
| 06/03/22 | Minnesota Twins placed LHP Caleb Thielbar on the restricted list. |
| 06/03/22 | Minnesota Twins placed RF Max Kepler on the restricted list. |
| 06/03/22 | Minnesota Twins placed RHP Trevor Megill on the restricted list. |
| 06/03/22 | Minnesota Twins recalled OF Mark Contreras from St. Paul Saints. |
| 06/03/22 | Minnesota Twins selected the contract of RHP Jharel Cotton from St. Paul Saints. |
| 06/03/22 | Minnesota Twins selected the contract of RHP Ian Hamilton from St. Paul Saints. |
| 06/03/22 | Minnesota Twins selected the contract of RHP Chi Chi Gonzalez from St. Paul Saints. |
| 06/02/22 | Minnesota Twins signed free agent RHP Jose Ojo to a minor league contract. |
| 06/02/22 | Minnesota Twins signed free agent C Daniel Pena to a minor league contract. |
| 06/02/22 | Minnesota Twins placed RHP Sonny Gray on the 15-day injured list retroactive to May 30, 2022. Right pectoral strain. |
| 06/02/22 | Minnesota Twins recalled RHP Yennier Cano from St. Paul Saints. |
| 06/01/22 | Minnesota Twins optioned RHP Cole Sands to St. Paul Saints. |