Twins Roster & Staff
Transactions
| Date | Transaction |
| 05/31/18 | Minnesota Twins recalled Tyler Duffey from Rochester Red Wings. |
| 05/31/18 | Minnesota Twins optioned RHP Aaron Slegers to Rochester Red Wings. |
| 05/30/18 | Minnesota Twins recalled Aaron Slegers from Rochester Red Wings. |
| 05/30/18 | Byron Buxton roster status changed by Minnesota Twins. |
| 05/29/18 | Minnesota Twins traded RHP Myles Jaye to Cleveland Indians for cash. |
| 05/29/18 | Minnesota Twins sent RHP Ervin Santana on a rehab assignment to Fort Myers Miracle. |
| 05/28/18 | Minnesota Twins claimed 1B Taylor Motter off waivers from Seattle Mariners. |
| 05/27/18 | Minnesota Twins traded RHP Phil Hughes and Future Considerations to San Diego Padres for C Janigson Villalobos. |
| 05/27/18 | Minnesota Twins traded RHP Phil Hughes and Future Considerations to San Diego Padres for C Janigson Villalobos. |
| 05/24/18 | Miguel Sano roster status changed by Minnesota Twins. |
| 05/24/18 | Minnesota Twins optioned RF Jake Cave to Rochester Red Wings. |
| 05/23/18 | Minnesota Twins sent RHP Ervin Santana on a rehab assignment to Chattanooga Lookouts. |
| 05/22/18 | Minnesota Twins recalled Ryan LaMarre from Rochester Red Wings. |
| 05/22/18 | Los Angeles Angels traded 1B Chris Carter to Minnesota Twins for cash. |
| 05/22/18 | Minnesota Twins designated RHP Phil Hughes for assignment. |
| 05/19/18 | Minnesota Twins sent 3B Miguel Sano on a rehab assignment to Rochester Red Wings. |
| 05/19/18 | Minnesota Twins placed 1B Joe Mauer on the 10-day disabled list. Cervical strain and concussion-like symptoms. |
| 05/19/18 | Minnesota Twins recalled Jake Cave from Rochester Red Wings. |
| 05/12/18 | Minnesota Twins sent RHP Trevor May on a rehab assignment to Fort Myers Miracle. |
| 05/10/18 | Minnesota Twins optioned CF Ryan LaMarre to Rochester Red Wings. |
| 05/10/18 | Minnesota Twins placed CF Byron Buxton on the 10-day disabled list. Left great toe fracture. |
| 05/09/18 | Minnesota Twins traded LHP Anthony McIver to Seattle Mariners for cash. |
| 05/08/18 | Minnesota Twins signed free agent RHP Alex Banks to a minor league contract. |
| 05/07/18 | Minnesota Twins sent LHP Dietrich Enns outright to Rochester Red Wings. |
| 05/05/18 | Minnesota Twins traded RHP Max Cordy to Los Angeles Angels. |
| 05/05/18 | Minnesota Twins placed C Jason Castro on the 10-day disabled list. Right knee meniscus tear. |
| 05/05/18 | Minnesota Twins transferred RHP Ervin Santana from the 10-day disabled list to the 60-day disabled list. Right third finger. |
| 05/05/18 | Minnesota Twins selected the contract of C Bobby Wilson from Rochester Red Wings. |
| 05/04/18 | Minnesota Twins signed free agent LHP Paco Rodriguez to a minor league contract. |
| 05/02/18 | Minnesota Twins optioned RHP John Curtiss to Rochester Red Wings. |
| 05/02/18 | Minnesota Twins recalled Fernando Romero from Rochester Red Wings. |
| 05/01/18 | Minnesota Twins placed 3B Miguel Sano on the 10-day disabled list retroactive to April 28, 2018. Left hamstring strain. |
| 05/01/18 | RHP Tyler Kinley returned to Miami Marlins from Minnesota Twins. |
| 05/01/18 | Minnesota Twins designated LHP Dietrich Enns for assignment. |
| 05/01/18 | Minnesota Twins selected the contract of SS Gregorio Petit from Rochester Red Wings. |