D-backs Roster & Staff
Transactions
| Date | Transaction |
| 08/29/22 | Arizona Diamondbacks activated LHP Caleb Smith from the 15-day injured list. |
| 08/29/22 | Arizona Diamondbacks optioned LHP Tyler Holton to Reno Aces. |
| 08/29/22 | Arizona Diamondbacks optioned LF Jordan Luplow to Reno Aces. |
| 08/29/22 | Arizona Diamondbacks selected the contract of CF Corbin Carroll, , , , and from Reno Aces. |
| 08/27/22 | Arizona Diamondbacks released RHP Chris Devenski. |
| 08/26/22 | Arizona Diamondbacks sent LHP Caleb Smith on a rehab assignment to Reno Aces. |
| 08/26/22 | Arizona Diamondbacks sent LHP Caleb Smith on a rehab assignment to Reno Aces. |
| 08/26/22 | Arizona Diamondbacks sent LHP Caleb Smith on a rehab assignment to Reno Aces. |
| 08/26/22 | Arizona Diamondbacks sent LHP Kyle Nelson on a rehab assignment to Reno Aces. |
| 08/26/22 | Arizona Diamondbacks sent LHP Kyle Nelson on a rehab assignment to Reno Aces. |
| 08/25/22 | Arizona Diamondbacks activated RHP Reyes Moronta. |
| 08/25/22 | Arizona Diamondbacks designated RHP Chris Devenski for assignment. |
| 08/24/22 | Arizona Diamondbacks sent SS Jake Hager outright to Reno Aces. |
| 08/23/22 | Arizona Diamondbacks sent LHP Caleb Smith on a rehab assignment to ACL D-backs Black. |
| 08/23/22 | Arizona Diamondbacks designated SS Jake Hager for assignment. |
| 08/23/22 | Arizona Diamondbacks sent RHP Keynan Middleton on a rehab assignment to Reno Aces. |
| 08/23/22 | Arizona Diamondbacks sent LHP Caleb Smith on a rehab assignment to ACL D-backs Black. |
| 08/22/22 | Arizona Diamondbacks claimed RHP Reyes Moronta off waivers from Los Angeles Dodgers. |
| 08/21/22 | Arizona Diamondbacks recalled RHP Luis Frias from Reno Aces. |
| 08/21/22 | Arizona Diamondbacks optioned RHP Edwin Uceta to Reno Aces. |
| 08/19/22 | Arizona Diamondbacks sent RHP Keynan Middleton on a rehab assignment to ACL D-backs Red. |
| 08/19/22 | Arizona Diamondbacks signed free agent RHP Frederic Frias to a minor league contract. |
| 08/19/22 | Arizona Diamondbacks signed free agent RHP Garrett Leonard to a minor league contract. |
| 08/19/22 | Arizona Diamondbacks sent LHP Paul Fry outright to Reno Aces. |
| 08/17/22 | Arizona Diamondbacks designated LHP Paul Fry for assignment. |
| 08/17/22 | Arizona Diamondbacks optioned OF Seth Beer to Reno Aces. |
| 08/17/22 | Arizona Diamondbacks selected the contract of CF Stone Garrett from Reno Aces. |
| 08/16/22 | Arizona Diamondbacks recalled OF Seth Beer and from Reno Aces. |
| 08/13/22 | Arizona Diamondbacks signed free agent RHP Caswell Smith to a minor league contract. |
| 08/09/22 | Arizona Diamondbacks recalled C Cooper Hummel from Reno Aces. |
| 08/09/22 | Arizona Diamondbacks optioned C Jose Herrera to Reno Aces. |
| 08/08/22 | Arizona Diamondbacks placed LHP Kyle Nelson on the 15-day injured list retroactive to August 5, 2022. Lower back spasms. |
| 08/08/22 | Arizona Diamondbacks recalled RHP Edwin Uceta from Reno Aces. |
| 08/03/22 | Arizona Diamondbacks transferred LHP Tyler Gilbert from the 15-day injured list to the 60-day injured list. Left elbow sprain. |
| 08/03/22 | Arizona Diamondbacks selected the contract of LHP Tommy Henry from Reno Aces. |
| 08/03/22 | Arizona Diamondbacks optioned RHP Taylor Widener to Reno Aces. |
| 08/02/22 | Arizona Diamondbacks placed 3B Emmanuel Rivera on the 60-day injured list. Fractured left wrist. |
| 08/02/22 | Arizona Diamondbacks activated 3B Emmanuel Rivera. |
| 08/02/22 | Arizona Diamondbacks optioned 3B Buddy Kennedy to Reno Aces. |
| 08/01/22 | Arizona Diamondbacks activated RHP Kevin Ginkel. |
| 08/01/22 | Arizona Diamondbacks activated RHP Zach Davies from the 15-day injured list. |
| 08/01/22 | Arizona Diamondbacks signed RHP Landon Green. |
| 08/01/22 | Arizona Diamondbacks activated RHP Kevin Ginkel. |
| 08/01/22 | Arizona Diamondbacks placed LHP Caleb Smith on the 15-day injured list. Right hand fracture. |
| 08/01/22 | Arizona Diamondbacks signed RHP Tyler Stone. |
| 08/01/22 | Arizona Diamondbacks selected the contract of RHP Kevin Ginkel from Reno Aces. |
| 08/01/22 | Arizona Diamondbacks recalled RHP Taylor Widener from Reno Aces. |
| 08/01/22 | Arizona Diamondbacks traded RHP Luke Weaver to Kansas City Royals for 3B Emmanuel Rivera. |
| 08/01/22 | Arizona Diamondbacks traded RHP Luke Weaver to Kansas City Royals for 3B Emmanuel Rivera. |
| 08/01/22 | Arizona Diamondbacks optioned 2B Yonny Hernandez to Reno Aces. |
| 08/01/22 | Arizona Diamondbacks optioned RHP Corbin Martin to Reno Aces. |