Red Sox Roster & Staff
Transactions
| Date | Transaction |
| 04/29/22 | Boston Red Sox activated RHP Tanner Houck from the restricted list. |
| 04/29/22 | Boston Red Sox signed free agent OF Cristofher Paniagua to a minor league contract. |
| 04/29/22 | Boston Red Sox activated RHP Kutter Crawford from the restricted list. |
| 04/29/22 | Boston Red Sox designated 3B Travis Shaw for assignment. |
| 04/29/22 | 2B Rob Refsnyder returned to Worcester Red Sox from Boston Red Sox. |
| 04/29/22 | Boston Red Sox selected the contract of CF Franchy Cordero and from Worcester Red Sox. |
| 04/29/22 | RHP John Schreiber returned to Worcester Red Sox from Boston Red Sox. |
| 04/29/22 | RHP Tyler Danish returned to Worcester Red Sox from Boston Red Sox. |
| 04/29/22 | Boston Red Sox recalled RF Jaylin Davis from Worcester Red Sox. |
| 04/28/22 | Boston Red Sox optioned RF Jaylin Davis to Worcester Red Sox. |
| 04/28/22 | Boston Red Sox claimed RF Jaylin Davis off waivers from San Francisco Giants. |
| 04/26/22 | Boston Red Sox sent LHP Josh Taylor on a rehab assignment to Worcester Red Sox. |
| 04/25/22 | Boston Red Sox activated C Kevin Plawecki from the 10-day injured list. |
| 04/25/22 | Boston Red Sox placed RHP Tanner Houck on the restricted list. |
| 04/25/22 | Boston Red Sox placed RHP Kutter Crawford on the restricted list. |
| 04/25/22 | Boston Red Sox selected the contract of RHP John Schreiber from Worcester Red Sox. |
| 04/25/22 | Boston Red Sox recalled RHP Tyler Danish from Worcester Red Sox. |
| 04/25/22 | Boston Red Sox optioned C Connor Wong to Worcester Red Sox. |
| 04/24/22 | Boston Red Sox activated LHP Rich Hill from the bereavement list. |
| 04/24/22 | Boston Red Sox sent LHP Josh Taylor on a rehab assignment to Portland Sea Dogs. |
| 04/24/22 | Boston Red Sox optioned RHP Tyler Danish to Worcester Red Sox. |
| 04/22/22 | Boston Red Sox signed free agent RHP Andres Jimenez to a minor league contract. |
| 04/20/22 | Boston Red Sox activated C Christian Vazquez from the 10-day injured list. |
| 04/20/22 | Boston Red Sox optioned C Ronaldo Hernandez to Worcester Red Sox. |
| 04/19/22 | Boston Red Sox placed C Christian Vazquez on the 10-day injured list. |
| 04/19/22 | Boston Red Sox placed LHP Rich Hill on the bereavement list. |
| 04/19/22 | Boston Red Sox placed SS Jonathan Arauz on the 10-day injured list. |
| 04/19/22 | Boston Red Sox selected the contract of 2B Rob Refsnyder from Worcester Red Sox. |
| 04/19/22 | Boston Red Sox recalled RHP Tyler Danish from Worcester Red Sox. |
| 04/19/22 | Boston Red Sox recalled C Ronaldo Hernandez from Worcester Red Sox. |
| 04/18/22 | Boston Red Sox placed C Kevin Plawecki on the 10-day injured list. |
| 04/18/22 | Boston Red Sox recalled C Connor Wong from Worcester Red Sox. |
| 04/17/22 | Boston Red Sox sent LHP Josh Taylor on a rehab assignment to Worcester Red Sox. |
| 04/10/22 | Boston Red Sox sent RHP Eduard Bazardo outright to Worcester Red Sox. |
| 04/07/22 | Boston Red Sox designated RHP Ralph Garza Jr. for assignment. |
| 04/07/22 | Boston Red Sox selected the contract of RHP Hansel Robles, and from Worcester Red Sox. |
| 04/07/22 | Boston Red Sox optioned RHP Tyler Danish to Worcester Red Sox. |
| 04/07/22 | Boston Red Sox selected the contract of 3B Travis Shaw, and from Worcester Red Sox. |
| 04/07/22 | Tampa Bay Rays claimed RHP Ralph Garza Jr. off waivers from Boston Red Sox. |
| 04/05/22 | OF Miguel Bleis and assigned to Boston Red Sox. |
| 04/05/22 | SS Luis Ravelo and assigned to Boston Red Sox. |
| 04/05/22 | 2B Ahbram Liendo and assigned to Boston Red Sox. |
| 04/05/22 | OF Darel Belen and assigned to Boston Red Sox. |
| 04/05/22 | C Diego Viloria and assigned to Boston Red Sox. |
| 04/05/22 | C Ronald Rosario roster status changed by Boston Red Sox. |
| 04/05/22 | OF Bryan Gonzalez and assigned to Boston Red Sox. |
| 04/05/22 | 3B Johnfrank Salazar and assigned to Boston Red Sox. |
| 04/05/22 | C Ronald Rosario assigned to Boston Red Sox. |
| 04/04/22 | Boston Red Sox activated RHP Kutter Crawford. |
| 04/04/22 | RF Miguel Ugueto and assigned to Boston Red Sox. |
| 04/04/22 | Boston Red Sox placed LHP Josh Taylor on the 10-day injured list. Low back strain,. |
| 04/04/22 | C Yorberto Mejicano and assigned to Boston Red Sox. |
| 04/04/22 | RHP Joey Stock and assigned to Boston Red Sox. |
| 04/04/22 | Boston Red Sox placed LHP Chris Sale on the 60-day injured list. Right rib stress fracture. |
| 04/04/22 | RF Juan Chacon and assigned to Boston Red Sox. |
| 04/04/22 | Boston Red Sox selected the contract of RHP Tyler Danish from Worcester Red Sox. |
| 04/03/22 | SS Antoni Flores and assigned to Boston Red Sox. |
| 04/02/22 | IF Alex Erro and assigned to Boston Red Sox. |
| 04/02/22 | Boston Red Sox optioned RHP Eduard Bazardo to Worcester Red Sox. |
| 04/02/22 | Boston Red Sox optioned LHP Darwinzon Hernandez to Worcester Red Sox. |
| 04/01/22 | RHP Jacob Webb and assigned to Boston Red Sox. |