Red Sox Roster & Staff
Transactions
| Date | Transaction |
| 05/28/21 | Boston Red Sox recalled RHP Colten Brewer from Worcester Red Sox. |
| 05/27/21 | Boston Red Sox optioned CF Franchy Cordero to Worcester Red Sox. |
| 05/25/21 | Boston Red Sox sent RHP Austin Brice outright to Worcester Red Sox. |
| 05/25/21 | Boston Red Sox activated 3B Christian Arroyo. |
| 05/24/21 | Boston Red Sox optioned 2B Michael Chavis to Worcester Red Sox. |
| 05/21/21 | Boston Red Sox selected the contract of SS Danny Santana from Worcester Red Sox. |
| 05/21/21 | Boston Red Sox designated RHP Austin Brice for assignment. |
| 05/21/21 | Boston Red Sox sent 3B Christian Arroyo on a rehab assignment to Worcester Red Sox. |
| 05/18/21 | Boston Red Sox activated CF Enrique Hernandez. |
| 05/17/21 | Boston Red Sox optioned SS Jonathan Arauz to Worcester Red Sox. |
| 05/16/21 | Boston Red Sox optioned RHP Colten Brewer to Worcester Red Sox. |
| 05/16/21 | Boston Red Sox activated RHP Garrett Whitlock from the 10-day injured list. |
| 05/15/21 | Boston Red Sox recalled RHP Colten Brewer from Worcester Red Sox. |
| 05/15/21 | Boston Red Sox placed RHP Garrett Whitlock on the 10-day injured list. |
| 05/15/21 | Boston Red Sox sent CF Enrique Hernandez on a rehab assignment to Worcester Red Sox. |
| 05/13/21 | Boston Red Sox activated RHP Nick Pivetta from the 10-day injured list. |
| 05/13/21 | Boston Red Sox optioned RHP Eduard Bazardo to Worcester Red Sox. |
| 05/12/21 | Boston Red Sox recalled RHP Eduard Bazardo from Worcester Red Sox. |
| 05/12/21 | Boston Red Sox placed RHP Nick Pivetta on the 10-day injured list. |
| 05/09/21 | Boston Red Sox recalled SS Jonathan Arauz from Worcester Red Sox. |
| 05/09/21 | Boston Red Sox placed 3B Christian Arroyo on the 10-day injured list. Left hand contusion. |
| 05/07/21 | Boston Red Sox recalled 2B Michael Chavis from Worcester Red Sox. |
| 05/07/21 | Boston Red Sox placed CF Enrique Hernandez on the 10-day injured list. |
| 05/06/21 | Boston Red Sox signed free agent RHP Brandon Workman to a minor league contract. |
| 05/03/21 | Boston Red Sox claimed RHP Brandon Brennan off waivers from Seattle Mariners. |
| 05/03/21 | Boston Red Sox placed RHP Ryan Brasier on the 60-day injured list. Left calf strain. |
| 05/03/21 | Boston Red Sox optioned RHP Brandon Brennan to Worcester Red Sox. |