After leaving the game with no outs in the second inning and nine Dodgers runs having already scored, D-backs left-hander Caleb Smith took his frustration out on a Gatorade cooler in Arizona's dugout.

Believe it or not, things only got worse for the D-backs after that.

The Dodgers hit eight home runs, including two grand slams, as they handed the D-backs their most lopsided loss in franchise history, a 22-1 beatdown on Saturday night at Dodger Stadium.

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It was Arizona's all-time largest margin of defeat and also the most runs it's allowed in a game.

It added up to an ugly night for the visitors.

The tone was set early as the Dodgers blitzed Smith for five runs in the first inning, thanks in part to back-to-back homers by Cody Bellinger and AJ Pollock. In the second, Smith allowed a leadoff single to pitcher Walker Buehler and walked the next two batters, before giving up a grand slam to Justin Turner, which pushed the Dodgers' lead to 9-0 and ended Smith's night.

It was the second straight subpar outing for Smith, who has allowed 14 runs in seven innings over that stretch.

"I just saw some misfires out over the plate," D-backs manager Torey Lovullo said. "He put a couple of runners on via the walk, and they were building innings against him. I thought there were some key slugging moments where they got their hands on a pitch and put up some crooked numbers."

It only got worse from there, as the Dodgers scored seven runs in the seventh and six more in the ninth, when the D-backs used outfielder Josh Reddick to finish off the game on the mound.

"We got our butts kicked," Lovullo said. "And I don't like it. I don't think anybody in that clubhouse likes it. So we've got to find a way to get better and stop games like that from happening. It's unacceptable."

The performance came after one of the D-backs' best games of the year. On Friday night, they played a clean game, showing good plate discipline, playing solid defense and not making any mental mistakes.

"The thing that's confusing to me is how we can be so good one day and have this happen," Lovullo said. "But baseball is a funny game."

While not amused by his team's performance, Lovullo said he did not believe that Saturday was the low point of the D-backs' season.

That speaks more to the rough year that Arizona has had to this point, which includes losing streaks of 13 and 17 games, the latter of which set a franchise record. The D-backs also lost an MLB-record 24 straight games on the road during one stretch.

"That ought to tell you the kind of season we've had," Lovullo said. "You know, you lose 20-plus games on the road, you're fighting a 16- or 17-game losing streak, whatever that number was. I think, for me, we're on the rise. We're in a different spot. So now I think we're well beyond our worst days here."