Cubs Roster & Staff
Transactions
| Date | Transaction |
| 08/31/22 | Chicago Cubs sent LHP Wade Miley on a rehab assignment to South Bend Cubs. |
| 08/31/22 | LHP Brendon Little roster status changed by Chicago Cubs. |
| 08/30/22 | Chicago Cubs selected the contract of RHP Jeremiah Estrada from Iowa Cubs. |
| 08/29/22 | Chicago Cubs placed RHP Adrian Sampson on the restricted list. |
| 08/29/22 | Chicago Cubs placed LHP Justin Steele on the restricted list. |
| 08/29/22 | Chicago Cubs selected the contract of LHP Brendon Little from Iowa Cubs. |
| 08/27/22 | Chicago Cubs placed 3B Patrick Wisdom on the 10-day injured list retroactive to August 26, 2022. |
| 08/27/22 | Chicago Cubs sent RHP Adbert Alzolay on a rehab assignment to Iowa Cubs. |
| 08/27/22 | Chicago Cubs recalled 1B Alfonso Rivas from Iowa Cubs. |
| 08/26/22 | Chicago Cubs transferred RHP Alec Mills from the 15-day injured list to the 60-day injured list. |
| 08/26/22 | Chicago Cubs activated RHP Manuel Rodriguez from the 60-day injured list. |
| 08/26/22 | Chicago Cubs optioned RHP Kervin Castro to Iowa Cubs. |
| 08/25/22 | Chicago Cubs sent RF Michael Hermosillo on a rehab assignment to Iowa Cubs. |
| 08/25/22 | Chicago Cubs sent RF Michael Hermosillo on a rehab assignment to Iowa Cubs. |
| 08/24/22 | Chicago Cubs reassigned RHP Nicholas Padilla to the minor leagues. |
| 08/24/22 | Chicago Cubs transferred RHP Kyle Hendricks from the 15-day injured list to the 60-day injured list. Right shoulder strain. |
| 08/24/22 | Chicago Cubs placed LHP Steven Brault on the 15-day injured list. Left shoulder strain. |
| 08/24/22 | RHP Nicholas Padilla returned to Iowa Cubs from Chicago Cubs. |
| 08/24/22 | Chicago Cubs optioned RHP Anderson Espinoza to Iowa Cubs. |
| 08/24/22 | Chicago Cubs recalled RHP Kervin Castro from Iowa Cubs. |
| 08/24/22 | Chicago Cubs selected the contract of RHP Luke Farrell from Iowa Cubs. |
| 08/23/22 | Chicago Cubs activated RHP Nicholas Padilla. |
| 08/23/22 | Chicago Cubs transferred RF Jason Heyward from the 10-day injured list to the 60-day injured list. |
| 08/23/22 | Chicago Cubs selected the contract of RHP Javier Assad from Iowa Cubs. |
| 08/23/22 | Chicago Cubs optioned RHP Kervin Castro to Iowa Cubs. |
| 08/23/22 | Chicago Cubs selected the contract of RHP Nicholas Padilla from Iowa Cubs. |
| 08/22/22 | Chicago Cubs sent RHP Adbert Alzolay on a rehab assignment to ACL Cubs. |
| 08/22/22 | Chicago Cubs sent RHP Adbert Alzolay on a rehab assignment to ACL Cubs. |
| 08/20/22 | Chicago Cubs recalled RHP Anderson Espinoza from Iowa Cubs. |
| 08/18/22 | Chicago Cubs sent RF Michael Hermosillo on a rehab assignment to ACL Cubs. |
| 08/18/22 | Chicago Cubs sent RF Michael Hermosillo on a rehab assignment to ACL Cubs. |
| 08/17/22 | Chicago Cubs activated LHP Steven Brault from the 10-day injured list. |
| 08/17/22 | Chicago Cubs sent RHP Manuel Rodriguez on a rehab assignment to Iowa Cubs. |
| 08/17/22 | Chicago Cubs optioned RHP Anderson Espinoza to Iowa Cubs. |
| 08/12/22 | Chicago Cubs sent LHP Steven Brault on a rehab assignment to Iowa Cubs. |
| 08/12/22 | 1B Alfonso Rivas returned to Iowa Cubs from Chicago Cubs. |
| 08/11/22 | Chicago Cubs reassigned 1B Alfonso Rivas to the minor leagues. |
| 08/11/22 | Chicago Cubs recalled 1B Alfonso Rivas from Iowa Cubs. |
| 08/09/22 | Chicago Cubs sent RHP Manuel Rodriguez on a rehab assignment to ACL Cubs. |
| 08/09/22 | Chicago Cubs activated RF Franmil Reyes. |
| 08/09/22 | Chicago Cubs sent RHP Manuel Rodriguez on a rehab assignment to ACL Cubs. |
| 08/09/22 | Chicago Cubs optioned 1B Frank Schwindel to Iowa Cubs. |
| 08/08/22 | Chicago Cubs claimed RF Franmil Reyes off waivers from Cleveland Guardians. |
| 08/07/22 | Chicago Cubs released SS Andrelton Simmons. |
| 08/06/22 | Chicago Cubs designated SS Andrelton Simmons for assignment. |
| 08/06/22 | Chicago Cubs activated SS Andrelton Simmons from the 10-day injured list. |
| 08/05/22 | Chicago Cubs optioned LHP Matt Dermody to Iowa Cubs. |
| 08/04/22 | Chicago Cubs reassigned LHP Matt Dermody to the minor leagues. |
| 08/04/22 | Chicago Cubs activated LHP Sean Newcomb. |
| 08/04/22 | Chicago Cubs recalled LHP Matt Dermody from Iowa Cubs. |
| 08/04/22 | Chicago Cubs selected the contract of LHP Sean Newcomb from Iowa Cubs. |
| 08/04/22 | Chicago Cubs optioned 2B David Bote to Iowa Cubs. |
| 08/03/22 | Chicago Cubs sent LHP Wade Miley on a rehab assignment to Iowa Cubs. |
| 08/03/22 | Chicago Cubs sent LHP Wade Miley on a rehab assignment to Iowa Cubs. |
| 08/03/22 | Chicago Cubs recalled RHP Kervin Castro from Iowa Cubs. |
| 08/02/22 | Chicago Cubs placed LHP Steven Brault on the 10-day injured list. |
| 08/02/22 | Chicago Cubs signed free agent RHP Grant Kipp to a minor league contract. |
| 08/02/22 | Chicago Cubs placed 2B Nick Madrigal on the 10-day injured list. Right groin strain. |
| 08/02/22 | Chicago Cubs activated 2B Nick Madrigal from the 10-day injured list. |
| 08/02/22 | Chicago Cubs activated RHP Michael Rucker. |
| 08/02/22 | Chicago Cubs activated RHP Michael Rucker. |
| 08/02/22 | Chicago Cubs recalled RHP Anderson Espinoza from Iowa Cubs. |
| 08/02/22 | Chicago Cubs claimed RHP Kervin Castro off waivers from San Francisco Giants. |
| 08/02/22 | Chicago Cubs recalled RHP Michael Rucker from Iowa Cubs. |
| 08/02/22 | Chicago Cubs traded RHP Mychal Givens to New York Mets for RHP Saul Gonzalez. |
| 08/02/22 | Chicago Cubs traded RHP Mychal Givens to New York Mets for RHP Saul Gonzalez. |
| 08/02/22 | Chicago Cubs traded RHP David Robertson to Philadelphia Phillies for RHP Ben Brown. |
| 08/02/22 | Chicago Cubs traded RHP David Robertson to Philadelphia Phillies for RHP Ben Brown. |
| 08/01/22 | Chicago Cubs traded RHP Scott Effross to New York Yankees for RHP Hayden Wesneski. |
| 08/01/22 | Chicago Cubs traded RHP Scott Effross to New York Yankees for RHP Hayden Wesneski. |