Cubs Roster & Staff
Transactions
| Date | Transaction |
| 08/31/21 | Los Angeles Dodgers claimed RHP Ryan Meisinger off waivers from Chicago Cubs. |
| 08/31/21 | Los Angeles Dodgers claimed RHP Jake Jewell off waivers from Chicago Cubs. |
| 08/31/21 | Chicago Cubs sent C Willson Contreras on a rehab assignment to Iowa Cubs. |
| 08/28/21 | Chicago Cubs designated RHP Ryan Meisinger for assignment. |
| 08/28/21 | Chicago Cubs placed 2B David Bote on the 10-day injured list. Right ankle sprain. |
| 08/28/21 | Chicago Cubs selected the contract of 1B Alfonso Rivas from Iowa Cubs. |
| 08/28/21 | Chicago Cubs designated RHP Jake Jewell for assignment. |
| 08/28/21 | Chicago Cubs selected the contract of RHP Scott Effross, and from Iowa Cubs. |
| 08/26/21 | Chicago Cubs optioned RHP Jake Jewell to Iowa Cubs. |
| 08/25/21 | Chicago Cubs sent RHP Jonathan Holder on a rehab assignment to Iowa Cubs. |
| 08/25/21 | Chicago Cubs recalled RHP Jake Jewell from Iowa Cubs. |
| 08/25/21 | Chicago Cubs sent RHP Adbert Alzolay on a rehab assignment to Iowa Cubs. |
| 08/22/21 | Chicago Cubs sent 2B Nico Hoerner on a rehab assignment to South Bend Cubs. |
| 08/21/21 | Chicago Cubs optioned RHP Jake Jewell to Iowa Cubs. |
| 08/21/21 | Chicago Cubs recalled RHP Keegan Thompson from Iowa Cubs. |
| 08/20/21 | Chicago Cubs sent RHP Jonathan Holder on a rehab assignment to ACL Cubs. |
| 08/20/21 | Chicago Cubs sent RHP Jonathan Holder on a rehab assignment to ACL Cubs. |
| 08/20/21 | Chicago Cubs sent CF Johneshwy Fargas outright to Iowa Cubs. |
| 08/20/21 | Chicago Cubs released RHP Dan Winkler. |
| 08/19/21 | Chicago Cubs signed free agent RHP Marcus Walden to a minor league contract. |
| 08/18/21 | Chicago Cubs designated CF Johneshwy Fargas for assignment. |
| 08/18/21 | Chicago Cubs selected the contract of RHP Adrian Sampson from Iowa Cubs. |
| 08/17/21 | Chicago Cubs designated RHP Dan Winkler for assignment. |
| 08/17/21 | Chicago Cubs selected the contract of RF Michael Hermosillo from Iowa Cubs. |
| 08/15/21 | Chicago Cubs optioned 1B Greg Deichmann to Iowa Cubs. |
| 08/15/21 | Chicago Cubs activated RF Jason Heyward from the 10-day injured list. |
| 08/14/21 | Chicago Cubs placed RHP Adbert Alzolay on the 10-day injured list. Left hamstring strain. |
| 08/14/21 | Chicago Cubs sent LHP Kyle Ryan outright to Iowa Cubs. |
| 08/14/21 | Chicago Cubs recalled RHP Trevor Megill from Iowa Cubs. |
| 08/12/21 | Chicago Cubs selected the contract of RHP Ryan Meisinger from Iowa Cubs. |
| 08/12/21 | Chicago Cubs placed C Willson Contreras on the 10-day injured list. Right knee sprain. |
| 08/12/21 | Chicago Cubs activated C Austin Romine. |
| 08/12/21 | Chicago Cubs designated LHP Kyle Ryan for assignment. |
| 08/12/21 | Chicago Cubs released RHP Jake Arrieta. |
| 08/11/21 | Chicago Cubs sent RHP Dillon Maples on a rehab assignment to Iowa Cubs. |
| 08/11/21 | Chicago Cubs optioned LHP Kyle Ryan to Iowa Cubs. |
| 08/10/21 | Chicago Cubs recalled LHP Kyle Ryan from Iowa Cubs. |
| 08/10/21 | Chicago Cubs optioned RHP Trevor Megill to Iowa Cubs. |
| 08/10/21 | Chicago Cubs activated RHP Rowan Wick. |
| 08/10/21 | Chicago Cubs optioned LHP Kyle Ryan to Iowa Cubs. |
| 08/10/21 | Chicago Cubs recalled LHP Justin Steele, and from Iowa Cubs. |
| 08/07/21 | Chicago Cubs sent C Austin Romine on a rehab assignment to Iowa Cubs. |
| 08/06/21 | Chicago Cubs recalled 1B Greg Deichmann from Iowa Cubs. |
| 08/06/21 | Chicago Cubs placed RF Jason Heyward on the 10-day injured list. Left index finger inflammation. |