Cubs Roster & Staff
Transactions
| Date | Transaction |
| 04/30/21 | Chicago Cubs released RHP Brandon Workman. |
| 04/30/21 | Chicago Cubs recalled LHP Kyle Ryan from Iowa Cubs. |
| 04/30/21 | Chicago Cubs placed RHP Trevor Megill on the 10-day injured list. Right forearm strain. |
| 04/29/21 | Chicago Cubs recalled LHP Justin Steele from Cubs Alternate Training Site. |
| 04/29/21 | Chicago Cubs designated RHP Brandon Workman for assignment. |
| 04/27/21 | Chicago Cubs activated RHP Ryan Tepera. |
| 04/26/21 | Chicago Cubs optioned RHP Jason Adam to Cubs Alternate Training Site. |
| 04/26/21 | Chicago Cubs placed RHP Jonathan Holder on the 60-day injured list. Right shoulder strain. |
| 04/26/21 | Chicago Cubs selected the contract of RHP Trevor Megill from Cubs Alternate Training Site. |
| 04/26/21 | Chicago Cubs placed RHP Rowan Wick on the 60-day injured list. Left oblique strain. |
| 04/26/21 | Chicago Cubs placed C Austin Romine on the 10-day injured list. |
| 04/26/21 | Chicago Cubs selected the contract of C Tony Wolters from Cubs Alternate Training Site. |
| 04/25/21 | RHP Ryan Tepera roster status changed by Chicago Cubs. |
| 04/24/21 | Chicago Cubs recalled RHP Adbert Alzolay from Cubs Alternate Training Site. |
| 04/24/21 | Chicago Cubs optioned LHP Kyle Ryan to Cubs Alternate Training Site. |
| 04/23/21 | Chicago Cubs recalled LHP Kyle Ryan from Cubs Alternate Training Site. |
| 04/23/21 | Chicago Cubs placed RHP Shelby Miller on the 10-day injured list. Low back strain. |
| 04/22/21 | Chicago Cubs placed CF Joc Pederson on the 10-day injured list. Left wrist tendinitis. |
| 04/22/21 | Chicago Cubs recalled SS Nico Hoerner from Cubs Alternate Training Site. |
| 04/17/21 | Chicago Cubs optioned LHP Justin Steele to Cubs Alternate Training Site. |
| 04/17/21 | Chicago Cubs activated RHP Dan Winkler from the 10-day injured list. |
| 04/17/21 | RHP Pedro Strop returned to Cubs Alternate Training Site from Chicago Cubs. |
| 04/17/21 | Chicago Cubs activated RHP Brandon Workman from the 10-day injured list. |
| 04/17/21 | Chicago Cubs sent C Tony Wolters outright to Cubs Alternate Training Site. |
| 04/16/21 | Chicago Cubs activated 3B Matt Duffy from the 10-day injured list. |
| 04/16/21 | 2B Ildemaro Vargas returned to Cubs Alternate Training Site from Chicago Cubs. |
| 04/14/21 | Chicago Cubs selected the contract of P Shelby Miller. |
| 04/14/21 | Chicago Cubs optioned P Brad Wieck to Cubs Alternate Training Site. |
| 04/14/21 | Chicago Cubs activated C Austin Romine from the 10 day injured list. |
| 04/14/21 | Chicago Cubs activated P Jason Adam from the 10 day injured list. |
| 04/14/21 | Chicago Cubs optioned P Adbert Alzolay to Cubs Alternate Training Site. |
| 04/14/21 | Chicago Cubs designated C Tony Wolters for assignment. |
| 04/14/21 | Chicago Cubs activated C Austin Romine from the 10-day injured list. |
| 04/14/21 | Chicago Cubs activated RHP Jason Adam from the 10-day injured list. |
| 04/14/21 | Chicago Cubs selected the contract of RHP Shelby Miller. |
| 04/14/21 | Chicago Cubs activated C Austin Romine from the 10 day injured list. |
| 04/14/21 | Chicago Cubs activated P Jason Adam from the 10 day injured list. |
| 04/14/21 | Chicago Cubs selected the contract of P Shelby Miller from Cubs Alternate Training Site. |
| 04/13/21 | Chicago Cubs selected the contract of 2B Ildemaro Vargas. |
| 04/13/21 | Chicago Cubs selected the contract of 2B Ildemaro Vargas from Cubs Alternate Training Site. |
| 04/13/21 | Chicago Cubs placed 3B Matt Duffy on the 10 day injured list. |
| 04/12/21 | Chicago Cubs selected the contract of P Pedro Strop. |
| 04/12/21 | Chicago Cubs recalled P Justin Steele. |
| 04/12/21 | Chicago Cubs recalled LHP Justin Steele. |
| 04/12/21 | Chicago Cubs recalled P Justin Steele from Cubs Alternate Training Site. |
| 04/12/21 | Chicago Cubs recalled P Brad Wieck from Cubs Alternate Training Site. |
| 04/12/21 | Chicago Cubs selected the contract of RHP Pedro Strop. |
| 04/12/21 | Chicago Cubs placed P Jason Adam on the 10 day injured list. |
| 04/12/21 | Chicago Cubs placed P Brandon Workman on the 10 day injured list. |
| 04/12/21 | Chicago Cubs placed P Dan Winkler on the 10 day injured list. |
| 04/12/21 | Chicago Cubs selected the contract of P Pedro Strop from Cubs Alternate Training Site. |
| 04/05/21 | Chicago Cubs traded P James Norwood to San Diego Padres for P Dauris Valdez. |
| 04/05/21 | Chicago Cubs traded P James Norwood to San Diego Padres for P Dauris Valdez. |
| 04/01/21 | Chicago Cubs placed P Jonathan Holder on the 10 day disabled list. |
| 04/01/21 | CF Jake Marisnick changed number to 16. |
| 04/01/21 | Chicago Cubs placed C Austin Romine on the 10 day disabled list. |
| 04/01/21 | CF Jake Marisnick changed number to 42. |
| 04/01/21 | Chicago Cubs placed P Rowan Wick on the 10 day disabled list. |
| 04/01/21 | CF Jake Marisnick changed number to 6. |