Padres Roster & Staff
Transactions
| Date | Transaction |
| 12/28/22 | RHP Domingo Tapia roster status changed by San Diego Padres. |
| 12/28/22 | San Diego Padres signed free agent RHP Domingo Tapia to a minor league contract. |
| 12/28/22 | RHP Domingo Tapia roster status changed by San Diego Padres. |
| 12/22/22 | San Diego Padres activated RHP Seth Lugo. |
| 12/22/22 | San Diego Padres signed free agent RHP Seth Lugo. |
| 12/21/22 | LHP Miguel Cienfuegos assigned to San Diego Padres. |
| 12/21/22 | San Diego Padres signed free agent C Pedro Severino to a minor league contract. |
| 12/21/22 | C Pedro Severino roster status changed by San Diego Padres. |
| 12/20/22 | San Diego Padres activated DH Matt Carpenter. |
| 12/20/22 | San Diego Padres signed free agent DH Matt Carpenter. |
| 12/20/22 | San Diego Padres activated DH Matt Carpenter. |
| 12/20/22 | San Diego Padres activated DH Matt Carpenter. |
| 12/19/22 | San Diego Padres signed free agent 2B Max Schrock to a minor league contract. |
| 12/19/22 | San Diego Padres signed free agent SS Kelvin Melean to a minor league contract. |
| 12/19/22 | San Diego Padres signed free agent 2B Tim Lopes to a minor league contract. |
| 12/19/22 | San Diego Padres signed free agent 3B Brantley Bell to a minor league contract. |
| 12/19/22 | 2B Tim Lopes roster status changed by San Diego Padres. |
| 12/19/22 | 2B Max Schrock roster status changed by San Diego Padres. |
| 12/16/22 | San Diego Padres signed free agent LHP Brian Gonzalez to a minor league contract. |
| 12/15/22 | RHP Anderson Espinoza roster status changed by San Diego Padres. |
| 12/15/22 | San Diego Padres signed free agent RHP Anderson Espinoza to a minor league contract. |
| 12/15/22 | San Diego Padres signed free agent RHP Eric Hanhold to a minor league contract. |
| 12/15/22 | RHP Eric Hanhold roster status changed by San Diego Padres. |
| 12/15/22 | RHP Eric Hanhold roster status changed by San Diego Padres. |
| 12/12/22 | RHP Aaron Brooks roster status changed by San Diego Padres. |
| 12/12/22 | San Diego Padres signed free agent RHP Aaron Brooks to a minor league contract. |
| 12/10/22 | San Diego Padres signed free agent RHP Raul Brito to a minor league contract. |
| 12/10/22 | San Diego Padres signed free agent RHP Drew Carlton to a minor league contract. |
| 12/10/22 | RHP Drew Carlton roster status changed by San Diego Padres. |
| 12/10/22 | RHP Raul Brito roster status changed by San Diego Padres. |
| 12/09/22 | San Diego Padres activated SS Xander Bogaerts. |
| 12/09/22 | San Diego Padres signed free agent SS Xander Bogaerts. |
| 12/09/22 | LF Preston Tucker roster status changed by San Diego Padres. |
| 12/09/22 | San Diego Padres activated SS Xander Bogaerts. |
| 12/09/22 | San Diego Padres signed free agent LF Preston Tucker to a minor league contract. |
| 12/08/22 | San Diego Padres signed free agent RHP Henry Henry to a minor league contract. |
| 12/07/22 | San Diego Padres activated LHP Jose Lopez. |
| 12/07/22 | San Diego Padres claimed LHP Jose Lopez off waivers from Durham Bulls. |
| 12/05/22 | San Diego Padres signed free agent LF David Dahl to a minor league contract. |
| 12/05/22 | LF David Dahl roster status changed by San Diego Padres. |
| 12/02/22 | San Diego Padres activated RHP Sean Poppen. |
| 12/02/22 | San Diego Padres claimed RHP Sean Poppen off waivers from Arizona Diamondbacks. |