Padres Roster & Staff
Transactions
| Date | Transaction |
| 11/22/22 | San Diego Padres signed free agent RHP Nick Martinez, and. |
| 11/21/22 | San Diego Padres signed free agent RHP Efrain Contreras to a minor league contract. |
| 11/18/22 | RHP Efrain Contreras elected free agency. |
| 11/18/22 | C Jorge Alfaro elected free agency. |
| 11/17/22 | San Diego Padres signed free agent RHP Robert Suarez. |
| 11/15/22 | San Diego Padres activated LHP Tom Cosgrove. |
| 11/15/22 | San Diego Padres signed free agent RHP Bobby Milacki to a minor league contract. |
| 11/15/22 | San Diego Padres selected the contract of LHP Tom Cosgrove from El Paso Chihuahuas. |
| 11/10/22 | San Diego Padres activated RHP Pedro Avila. |
| 11/10/22 | RHP Nick Martinez elected free agency. |
| 11/10/22 | San Diego Padres selected the contract of RHP Pedro Avila from El Paso Chihuahuas. |
| 11/10/22 | San Diego Padres sent RHP Austin Adams outright to El Paso Chihuahuas. |
| 11/07/22 | 3B Jurickson Profar elected free agency. |
| 11/07/22 | 1B Wil Myers elected free agency. |
| 11/07/22 | San Diego Padres activated RHP Austin Adams from the 60-day injured list. |
| 11/07/22 | San Diego Padres activated LHP Drew Pomeranz from the 60-day injured list. |
| 11/07/22 | RHP Robert Suarez elected free agency. |
| 11/06/22 | RHP Pierce Johnson elected free agency. |
| 11/06/22 | RHP Mike Clevinger elected free agency. |
| 11/06/22 | LHP Sean Manaea elected free agency. |
| 11/06/22 | 1B Josh Bell elected free agency. |
| 11/06/22 | RHP Craig Stammen elected free agency. |
| 11/06/22 | 3B Brandon Drury elected free agency. |