Padres Roster & Staff
Transactions
| Date | Transaction |
| 07/31/21 | San Diego Padres placed SS Fernando Tatis Jr. on the 10-day injured list. Left shoulder inflammation. |
| 07/31/21 | San Diego Padres optioned RHP Nabil Crismatt to El Paso Chihuahuas. |
| 07/31/21 | San Diego Padres activated CF Jake Marisnick. |
| 07/31/21 | San Diego Padres placed RHP Chris Paddack on the 10-day injured list. |
| 07/31/21 | San Diego Padres recalled RHP Miguel Diaz from El Paso Chihuahuas. |
| 07/31/21 | San Diego Padres recalled RHP Reiss Knehr from El Paso Chihuahuas. |
| 07/30/21 | Washington Nationals traded RHP Daniel Hudson to San Diego Padres for RHP Mason Thompson. |
| 07/30/21 | San Diego Padres traded RHP Anderson Espinoza to Chicago Cubs for CF Jake Marisnick. |
| 07/30/21 | Washington Nationals traded RHP Daniel Hudson to San Diego Padres for RHP Mason Thompson. |
| 07/30/21 | San Diego Padres traded RHP Anderson Espinoza to Chicago Cubs for CF Jake Marisnick. |
| 07/28/21 | San Diego Padres signed RHP River Ryan. |
| 07/28/21 | IF River Ryan roster status changed by San Diego Padres. |
| 07/28/21 | San Diego Padres signed OF James Wood. |
| 07/27/21 | San Diego Padres activated 2B Adam Frazier. |
| 07/27/21 | San Diego Padres optioned CF Brian O'Grady to El Paso Chihuahuas. |
| 07/26/21 | San Diego Padres signed C Colton Bender. |
| 07/26/21 | San Diego Padres signed SS Jackson Merrill. |
| 07/26/21 | San Diego Padres optioned LHP Nick Ramirez to El Paso Chihuahuas. |
| 07/26/21 | San Diego Padres signed SS Marcos Castanon. |
| 07/26/21 | San Diego Padres signed free agent 3B Cole Cummings to a minor league contract. |
| 07/26/21 | San Diego Padres signed 2B Lucas Dunn. |
| 07/26/21 | San Diego Padres signed 2B Max Ferguson. |
| 07/26/21 | Pittsburgh Pirates traded 2B Adam Frazier and cash to San Diego Padres for SS Tucupita Marcano, RHP Michell Miliano and CF Jack Suwinski. |
| 07/26/21 | Pittsburgh Pirates traded 2B Adam Frazier and cash to San Diego Padres for SS Tucupita Marcano, RHP Michell Miliano and CF Jack Suwinski. |
| 07/26/21 | Pittsburgh Pirates traded 2B Adam Frazier and cash to San Diego Padres for SS Tucupita Marcano, RHP Michell Miliano and CF Jack Suwinski. |
| 07/26/21 | Pittsburgh Pirates traded 2B Adam Frazier and cash to San Diego Padres for SS Tucupita Marcano, RHP Michell Miliano and CF Jack Suwinski. |
| 07/24/21 | San Diego Padres activated LHP Ryan Weathers from the 10-day injured list. |
| 07/24/21 | San Diego Padres signed free agent RHP Brenden Heiss to a minor league contract. |
| 07/24/21 | San Diego Padres optioned RHP Miguel Diaz to El Paso Chihuahuas. |
| 07/23/21 | San Diego Padres activated RHP Craig Stammen from the paternity list. |
| 07/23/21 | San Diego Padres optioned LHP Daniel Camarena to El Paso Chihuahuas. |
| 07/22/21 | San Diego Padres optioned C Webster Rivas to El Paso Chihuahuas. |
| 07/22/21 | San Diego Padres activated 1B Austin Nola. |
| 07/22/21 | San Diego Padres sent LHP Nick Ramirez on a rehab assignment to El Paso Chihuahuas. |
| 07/22/21 | San Diego Padres optioned RHP Reiss Knehr to El Paso Chihuahuas. |
| 07/22/21 | San Diego Padres sent LHP Matt Strahm on a rehab assignment to El Paso Chihuahuas. |
| 07/21/21 | San Diego Padres recalled RHP Reiss Knehr from El Paso Chihuahuas. |
| 07/21/21 | San Diego Padres signed RHP Kobe Robinson. |
| 07/21/21 | San Diego Padres signed free agent LHP Ben Miller to a minor league contract. |
| 07/20/21 | San Diego Padres placed RHP Craig Stammen on the paternity list. |
| 07/20/21 | San Diego Padres recalled RHP Miguel Diaz from El Paso Chihuahuas. |
| 07/20/21 | San Diego Padres signed free agent RHP Ethan Routzahn to a minor league contract. |
| 07/20/21 | San Diego Padres sent LHP Matt Strahm on a rehab assignment to ACL Padres. |
| 07/20/21 | San Diego Padres signed RHP Luke Boyd. |
| 07/19/21 | San Diego Padres signed LHP Robert Gasser. |
| 07/19/21 | San Diego Padres signed RHP Alek Jacob. |
| 07/19/21 | San Diego Padres activated RHP Yu Darvish from the 10-day injured list. |
| 07/19/21 | San Diego Padres optioned RHP James Norwood to El Paso Chihuahuas. |
| 07/19/21 | San Diego Padres signed RHP Kevin Kopps. |
| 07/19/21 | San Diego Padres sent RHP Jordan Humphreys outright to San Antonio Missions. |
| 07/19/21 | San Diego Padres signed free agent RHP Aaron Northcraft to a minor league contract. |
| 07/19/21 | San Diego Padres signed RHP Garrett Hawkins. |
| 07/19/21 | San Diego Padres signed LHP Jackson Wolf. |
| 07/19/21 | San Diego Padres optioned RHP Miguel Diaz to El Paso Chihuahuas. |
| 07/18/21 | San Diego Padres recalled RHP James Norwood from El Paso Chihuahuas. |
| 07/17/21 | San Diego Padres activated LHP Blake Snell from the 10-day injured list. |
| 07/17/21 | San Diego Padres activated LHP Drew Pomeranz from the 10-day injured list. |
| 07/17/21 | San Diego Padres optioned RHP James Norwood to El Paso Chihuahuas. |
| 07/16/21 | San Diego Padres placed LHP Ryan Weathers on the 10-day injured list. Right ankle inflammation. |
| 07/13/21 | San Diego Padres released RHP Aaron Northcraft. |
| 07/11/21 | San Diego Padres placed RHP Yu Darvish on the 10-day injured list. |
| 07/11/21 | San Diego Padres recalled RHP Nabil Crismatt from El Paso Chihuahuas. |
| 07/10/21 | San Diego Padres optioned RHP Reiss Knehr to El Paso Chihuahuas. |
| 07/10/21 | San Diego Padres recalled CF Brian O'Grady from El Paso Chihuahuas. |
| 07/09/21 | San Diego Padres placed LHP Blake Snell on the 10-day injured list. Gastrointeritis. |
| 07/09/21 | San Diego Padres recalled RHP Miguel Diaz from El Paso Chihuahuas. |
| 07/09/21 | San Diego Padres placed LHP Drew Pomeranz on the 10-day injured list. Left forearm inflammation. |
| 07/09/21 | San Diego Padres designated RHP Aaron Northcraft for assignment. |
| 07/09/21 | San Diego Padres selected the contract of RHP Reiss Knehr from San Antonio Missions. |
| 07/09/21 | San Diego Padres sent 1B Austin Nola on a rehab assignment to El Paso Chihuahuas. |
| 07/08/21 | San Diego Padres recalled RHP James Norwood from El Paso Chihuahuas. |
| 07/08/21 | San Diego Padres recalled LHP Daniel Camarena from El Paso Chihuahuas. |
| 07/08/21 | San Diego Padres placed LHP Nick Ramirez on the 10-day injured list. |
| 07/08/21 | San Diego Padres optioned RHP Nabil Crismatt to El Paso Chihuahuas. |
| 07/04/21 | San Diego Padres optioned RHP Mason Thompson to El Paso Chihuahuas. |
| 07/04/21 | San Diego Padres activated LHP Blake Snell from the 10-day injured list. |
| 07/01/21 | San Diego Padres recalled LHP Ryan Weathers from El Paso Chihuahuas. |
| 07/01/21 | San Diego Padres signed free agent LHP Luke Westphal to a minor league contract. |
| 07/01/21 | San Diego Padres optioned RHP Miguel Diaz to El Paso Chihuahuas. |