Astros Roster & Staff
Transactions
| Date | Transaction |
| 09/30/22 | Houston Astros signed free agent RHP Julio Marte to a minor league contract. |
| 09/29/22 | Houston Astros recalled CF Jake Meyers from Sugar Land Space Cowboys. |
| 09/29/22 | Houston Astros optioned C Yainer Diaz to Sugar Land Space Cowboys. |
| 09/28/22 | Houston Astros signed free agent RHP Yefri Martinez to a minor league contract. |
| 09/23/22 | Houston Astros signed free agent RHP Jeremy Martinez to a minor league contract. |
| 09/16/22 | Houston Astros activated RHP Justin Verlander from the 15-day injured list. |
| 09/16/22 | Houston Astros optioned RHP Seth Martinez to Sugar Land Space Cowboys. |
| 09/16/22 | San Francisco Giants claimed 1B Taylor Jones off waivers from Houston Astros. |
| 09/13/22 | Houston Astros activated SS Aledmys Diaz from the 10-day injured list. |
| 09/13/22 | Houston Astros designated 1B Taylor Jones for assignment. |
| 09/13/22 | Houston Astros optioned 1B J.J. Matijevic to Sugar Land Space Cowboys. |
| 09/13/22 | Houston Astros optioned LHP Blake Taylor to Sugar Land Space Cowboys. |
| 09/09/22 | Houston Astros activated RHP Ryan Pressly from the 15-day injured list. |
| 09/09/22 | Houston Astros optioned RHP Brandon Bielak to Sugar Land Space Cowboys. |
| 09/08/22 | Houston Astros sent SS Aledmys Diaz on a rehab assignment to Sugar Land Space Cowboys. |
| 09/05/22 | Houston Astros signed free agent RHP Luis De La Cruz to a minor league contract. |
| 09/04/22 | Pittsburgh Pirates claimed RHP Peter Solomon off waivers from Houston Astros. |
| 09/02/22 | Houston Astros released 1B Niko Goodrum. |
| 09/01/22 | Houston Astros activated C Yainer Diaz. |
| 09/01/22 | Houston Astros designated RHP Peter Solomon for assignment. |
| 09/01/22 | Houston Astros designated 1B Niko Goodrum for assignment. |
| 09/01/22 | Houston Astros activated RHP Hunter Brown. |
| 09/01/22 | Houston Astros selected the contract of C Yainer Diaz from Sugar Land Space Cowboys. |
| 09/01/22 | Houston Astros selected the contract of RHP Hunter Brown from Sugar Land Space Cowboys. |