Astros Roster & Staff
Transactions
| Date | Transaction |
| 06/29/22 | Houston Astros sent RHP Jake Odorizzi on a rehab assignment to Corpus Christi Hooks. |
| 06/29/22 | Houston Astros sent RHP Jake Odorizzi on a rehab assignment to Corpus Christi Hooks. |
| 06/28/22 | Houston Astros signed free agent SS Darwin De Leon to a minor league contract. |
| 06/28/22 | Houston Astros placed LF Michael Brantley on the 10-day injured list retroactive to June 27, 2022. Rigt shoulder discomfort. |
| 06/28/22 | Houston Astros recalled RHP Enoli Paredes from Sugar Land Space Cowboys. |
| 06/28/22 | Houston Astros recalled RF Chas McCormick, , , and from Sugar Land Space Cowboys. |
| 06/27/22 | Houston Astros optioned RHP Brandon Bielak to Sugar Land Space Cowboys. |
| 06/27/22 | Los Angeles Angels claimed LF Dillon Thomas off waivers from Houston Astros. |
| 06/26/22 | Houston Astros activated SS Jeremy Peña from the 10-day injured list. |
| 06/26/22 | Houston Astros optioned RF Chas McCormick to Sugar Land Space Cowboys. |
| 06/24/22 | Houston Astros sent RHP Jake Odorizzi on a rehab assignment to Sugar Land Space Cowboys. |
| 06/24/22 | Houston Astros signed free agent SS Jose Robledo to a minor league contract. |
| 06/24/22 | Houston Astros designated LF Dillon Thomas for assignment. |
| 06/24/22 | Houston Astros optioned CF Jose Siri to Sugar Land Space Cowboys. |
| 06/23/22 | Houston Astros placed RHP Josh James on the 60-day injured list. Right lat strain. |
| 06/23/22 | Houston Astros recalled RHP Josh James from Sugar Land Space Cowboys. |
| 06/23/22 | Houston Astros optioned 1B Taylor Jones to Sugar Land Space Cowboys. |
| 06/18/22 | Houston Astros activated RHP Hector Neris. |
| 06/15/22 | Houston Astros placed CF Jake Meyers on the 60-day injured list. Left shoulder surgery. |
| 06/15/22 | Houston Astros placed SS Jeremy Pena on the 10-day injured list. Left thumb discomfort. |
| 06/15/22 | Houston Astros claimed LF Dillon Thomas and off waivers from Los Angeles Angels. |
| 06/15/22 | Houston Astros recalled 1B J.J. Matijevic from Sugar Land Space Cowboys. |
| 06/15/22 | Houston Astros optioned LF Dillon Thomas to Sugar Land Space Cowboys. |
| 06/14/22 | RHP Hector Neris roster status changed by Houston Astros. |
| 06/10/22 | Houston Astros signed free agent RHP Engel Daniel Peralta to a minor league contract. |
| 06/10/22 | Houston Astros signed free agent RHP Anthony Cruz to a minor league contract. |
| 06/10/22 | Houston Astros signed free agent RHP Jose Serrano to a minor league contract. |
| 06/10/22 | Houston Astros signed free agent RHP Jose Serrano to a minor league contract. |
| 06/07/22 | Houston Astros signed free agent RHP Juan Nunez to a minor league contract. |
| 06/07/22 | Houston Astros placed LHP Parker Mushinski on the 15-day injured list. Left elbow discomfort. |
| 06/07/22 | Houston Astros recalled RHP Brandon Bielak from Sugar Land Space Cowboys. |
| 06/04/22 | Houston Astros signed free agent RHP David Landeta to a minor league contract. |
| 06/04/22 | Houston Astros placed LHP Blake Taylor on the 15-day injured list. Left elbow discomfort. |
| 06/04/22 | Houston Astros recalled LHP Parker Mushinski from Sugar Land Space Cowboys. |
| 06/03/22 | Houston Astros sent 1B Taylor Jones on a rehab assignment to Sugar Land Space Cowboys. |
| 06/03/22 | Houston Astros sent CF Jake Meyers on a rehab assignment to Sugar Land Space Cowboys. |
| 06/03/22 | Houston Astros sent CF Jake Meyers on a rehab assignment to Sugar Land Space Cowboys. |
| 06/02/22 | Houston Astros signed free agent RHP Jonaiker Castellar to a minor league contract. |
| 06/01/22 | Houston Astros signed free agent RHP Wander Severino to a minor league contract. |
| 06/01/22 | Houston Astros signed free agent OF Karniel Pratt to a minor league contract. |
| 06/01/22 | Houston Astros signed free agent SS Alejandro Nunez to a minor league contract. |