Astros Roster & Staff
Transactions
| Date | Transaction |
| 05/31/21 | Houston Astros optioned RHP Ralph Garza Jr. to Sugar Land Skeeters. |
| 05/31/21 | Houston Astros optioned RHP Andre Scrubb to Sugar Land Skeeters. |
| 05/31/21 | Houston Astros activated LHP Blake Taylor. |
| 05/31/21 | Houston Astros activated RHP Jose Urquidy. |
| 05/30/21 | Houston Astros recalled RHP Nivaldo Rodriguez from Sugar Land Skeeters. |
| 05/30/21 | Houston Astros placed RHP Bryan Abreu on the 10-day injured list. Left calf strain. |
| 05/30/21 | Houston Astros optioned RHP Brandon Bielak to Sugar Land Skeeters. |
| 05/30/21 | Houston Astros recalled RHP Enoli Paredes from Sugar Land Skeeters. |
| 05/29/21 | Houston Astros optioned RHP Enoli Paredes to Sugar Land Skeeters. |
| 05/29/21 | Houston Astros activated RHP Jake Odorizzi. |
| 05/28/21 | Houston Astros placed LF Michael Brantley on the 10-day injured list. Tightness in right hamstring. |
| 05/28/21 | Houston Astros recalled 2B Robel Garcia from Sugar Land Skeeters. |
| 05/28/21 | Houston Astros recalled C Garrett Stubbs from Sugar Land Skeeters. |
| 05/28/21 | Houston Astros placed LHP Kent Emanuel on the 10-day injured list. Left elbow soreness. |
| 05/28/21 | Houston Astros placed C Jason Castro on the 10-day injured list. |
| 05/28/21 | Houston Astros activated LHP Framber Valdez from the 10-day injured list. |
| 05/26/21 | Houston Astros selected the contract of RHP Ralph Garza Jr. from Sugar Land Skeeters. |
| 05/26/21 | Houston Astros sent RHP Jose Urquidy on a rehab assignment to Corpus Christi Hooks. |
| 05/26/21 | Houston Astros placed RHP Josh James on the 60-day injured list. Recovery from left hip surgery. |
| 05/26/21 | Houston Astros placed RHP Lance McCullers Jr. on the 10-day injured list. Right shoulder soreness. |
| 05/25/21 | Houston Astros signed free agent RHP Jon Olczak to a minor league contract. |
| 05/23/21 | Houston Astros sent LHP Blake Taylor on a rehab assignment to Sugar Land Skeeters. |
| 05/22/21 | Houston Astros recalled 1B Taylor Jones from Sugar Land Skeeters. |
| 05/22/21 | Houston Astros optioned RHP Tyler Ivey to Sugar Land Skeeters. |
| 05/21/21 | Houston Astros recalled RHP Tyler Ivey from Sugar Land Skeeters. |
| 05/21/21 | Houston Astros optioned 2B Robel Garcia to Sugar Land Skeeters. |
| 05/17/21 | Houston Astros sent RHP Jake Odorizzi on a rehab assignment to Sugar Land Skeeters. |
| 05/16/21 | Houston Astros signed free agent RHP Daniel Procopio to a minor league contract. |
| 05/16/21 | Houston Astros sent LHP Framber Valdez on a rehab assignment to Sugar Land Skeeters. |
| 05/16/21 | Houston Astros placed RHP Jose Urquidy on the 10-day injured list. Right posterior shoulder discomfort. |
| 05/16/21 | Houston Astros activated RHP Enoli Paredes. |
| 05/11/21 | Houston Astros signed free agent RHP Michael Kelly to a minor league contract. |
| 05/08/21 | Houston Astros signed free agent SS Yadiel Rivera to a minor league contract. |
| 05/07/21 | Houston Astros signed free agent RHP Brandon Lawson to a minor league contract. |
| 05/06/21 | Houston Astros signed free agent RHP Nolan Riggs to a minor league contract. |
| 05/05/21 | Houston Astros sent RHP Enoli Paredes on a rehab assignment to Corpus Christi Hooks. |
| 05/04/21 | Houston Astros signed free agent RHP Ryan Eades to a minor league contract. |