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The future star didn’t collect his first career homer until his 81st at-bat, off Hall of Famer Goose Gossage in the second official night game at Wrigley Field.
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Biggio went 4-for-4 against the Rockies, becoming the fifth Astro to hit for the cycle.
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When he was hit by a pitch thrown by Byung-Hyun Kim, Biggio surpassed Don Baylor’s modern-day HBP record with 268.
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Down by one run with two outs in the ninth, the Astros star launched a three-run homer off former teammate and Phillies closer Billy Wagner in a key pennant-chase game.
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In his final season, Biggio cemented his Hall of Fame legacy by becoming the 27th player to reach 3,000 hits with a single off Aaron Cook.