The Houston Astros will begin the 2021 season on the road April 1 at Oakland, in what will be the first of a 4-game series vs. the Athletics. The 2021 Home Opener is scheduled for April 8, also vs. the Athletics, which will be the first of a six-game homestand at Minute Maid Park, April 8-14.

The 2021 season will be the 60th Major League season for the Houston franchise, which began in 1962 as the Colt .45s before becoming the Astros in 1965. The 2021 schedule will feature many exciting matchups as several popular opponents will visit Minute Maid Park, including the Boston Red Sox, Los Angeles Dodgers, New York Yankees and Texas Rangers.

THE WILD, WILD WEST

The 2021 schedule will once again feature 76 matchups vs. American League West opponents. The Astros, who have won three consecutive division titles, have received their biggest challenge within the division from the Athletics in recent years. Oakland, who finished second in the AL West in each of the last two seasons, earning a Wild Card berth both times, will be in Houston for nine games in 2021, including for the final three regular season games, Oct. 1-3. The Tampa Bay Rays, whom the Astros edged in the 2019 ALDS in five games, will also be in Houston on the final week of the 2021 season for a 3-game series, Sept. 28-30. 

The Astros and rival Texas Rangers will once again battle in the Lone Star Series for the Silver Boot, with Houston hosting the Rangers for three different series in 2021, totaling nine games at Minute Maid Park. Two of those series will be on weekends (May 13-16, July 23-25). In each of the past three seasons (2017-19), the Astros have won the season series to capture the Silver Boot.

The Los Angeles Angels of Anaheim, featuring baseball’s best player in Mike Trout and future Hall of Famer Albert Pujols, will visit Houston for four games in April (22-25), three games in May (10-12) and three more in September (10-12).

STORIED FRANCHISES

The Los Angeles Dodgers will return to Houston for a 2-game set, May 25-26. During that same homestand, the Boston Red Sox will also visit Minute Maid Park for a 4-game series, May 31-June 3. And, the New York Yankees will be in town for a 3-game series over the weekend of July 9-11. In addition to being three of baseball’s most storied franchises, the Dodgers, Red Sox and Yankees have also been three of baseball’s most successful and star-studded teams in recent years.

For Interleague Play, the Astros will face the NL West for the second consecutive season, with the San Diego Padres, Colorado Rockies, Arizona Diamondbacks and Dodgers scheduled to visit Houston in 2021.