SAN FRANCISCO -- Korey Lee made a big impact in his return to the Bay Area.

The White Sox catcher broke open a tie game in the ninth with a two-out, two-run single as Chicago’s four-run rally produced a 6-2 win over the Giants to cap the road trip on Wednesday afternoon at Oracle Park.

Lee, a three-year starting catcher at nearby University of California, lined a bases-loaded single to center on a 95 mph slider from Spencer Bivens after falling behind in the count, 0-2.

“Knew they were going to be aggressive to me,” Lee said. “Just got a good pitch, and staying through the middle is the name of the game in that AB.”

Lee flied out with two on and two outs in the ninth inning of Chicago’s 5-3 loss in the series opener on Monday.

“If you go back to the first game of the series, he had a chance in the ninth and had a great at-bat, and just came up short,” interim manager Grady Sizemore said. “Fast forward to here and see him come up big for us, just really happy for him.”

Lee had doubled against Bivens earlier in the series, which helped familiarize him with the reliever’s slider.

Among the friends and family in attendance to watch Lee on Wednesday was his brother Kellen, who was celebrating his 37th birthday.

“It was really, really special to me,” Lee said. “Don’t get to see him a whole lot, he’s been a big part of my career. ... [San Francisco] is part of home to me. Got a lot of family here, went to college 20 minutes away, not a cloud in the sky. It’s beautiful baseball weather.”

Lenyn Sosa followed Lee with a two-run single to add some insurance for the Sox, who won for just the fourth time in 34 games.

“We’re in all these games, we’re not giving up, and it’s nice to come out on top today,” said Sizemore, who improved to 3-8 since taking the managerial reins. “I’m really happy with how guys are fighting. To see them keep competing and not just fold and give in, they’re showing a lot of heart.”

Frasier Ellard, who made his Major League debut on July 30, pitched a scoreless eighth and struck out two to earn his first big league win.

“These guys are awesome, putting in the work every day,” said Ellard, the only lefty in Chicago’s bullpen. “I’m glad that I could play a small part in getting this win.”

Nicky Lopez led off the game with a triple against All-Star Logan Webb and scored in the first to give the Sox some early momentum. Lopez is batting .333 (8-for-24) to lead off games, which is tied for the fifth-highest average in the Majors (minimum 20 at-bats).

Luis Robert Jr. led off the fourth with a double and scored to give Chicago a 2-0 lead. Robert reached base three times, stole two bases and scored the winning run. Gavin Sheets singled twice and is now hitting .452 since Aug. 7, the highest mark in the Majors (minimum 30 at-bats) during that span.

Garrett Crochet gave up four hits and two runs in four innings to go with four strikeouts, before getting pulled after 57 pitches. Crochet, who is fifth in the Majors in strikeouts (180), is well past his previous career high for innings and has not pitched into the fifth in his past eight starts.

“He understands it,” Sizemore said about Crochet’s innings limit. “But he’s too much of a competitor to want to shut it down like that. I see it in his face every time.”

But the White Sox bullpen allowed just two baserunners in five innings. The win gives the Sox some momentum heading into a season-long 10-game homestand, which starts against the Tigers on Friday.