The late-inning magic from Opening Day was not there for the D-backs 24 hours later as they fell, 3-0, to the Padres at Chase Field on Friday night.

Here are four things to know from the game:

Beware of the lefties
The D-backs' struggles against left-handed pitchers was well documented last year, and it's something to keep an eye on again in 2022, after Padres southpaw Sean Manaea no-hit them for seven innings on Friday.

Arizona's lineup leans left-handed heavy, which is why it acquired right-handed-hitting outfielder Jordan Luplow from Tampa Bay this past offseason. But Luplow is on the injured list, so Cooper Hummel, a switch-hitter, is the only right-handed bat the D-backs can put in the outfield against lefty pitchers.

"It's too early for me to answer that question," Arizona manager Torey Lovullo said on whether lefties would pose a big challenge for his team going forward. "I believe in the guys we have out there."

Lovullo is right not to overreact to a dominant performance from Manaea, but it's something worth keeping an eye on as the season progresses.

Kelly looks good
Right-hander Merrill Kelly was dominant this spring, and he picked up where he left off in his first start of the season, tossing four scoreless innings.

Kelly would have pitched deeper into the game, but the Padres put together some good at-bats against him in the first inning, forcing him to throw 28 pitches. Kelly later needed 25 pitches to get through the fourth.

The average velocity on Kelly's four-seam fastball was 93.1 mph, per Statcast, which is 1.4 mph faster than his average from last year. In addition, the changeup that he worked so hard on this winter looked good.

"I haven't been happy with how it's been looking the past couple years," Kelly said. "So that was definitely an emphasis going into this season. I'm excited to see what it's doing so far."

The D-backs got the matchup they wanted
Lovullo decided to leave Thursday night's hero, Seth Beer, out of the lineup Friday in favor of the right-handed-hitting Hummel. Lovullo, though, said he was looking to get Beer up in a big moment with the right matchup, and he got it in the eighth.

With runners on the corners and two outs, Padres manager Bob Melvin removed left-hander Tim Hill in favor of righty Dinelson Lamet to face Drew Ellis. Louvllo countered with Beer, and after winning Thursday's game with a walk-off three-run homer, Beer jumped on the first pitch he saw from Lamet -- a 96 mph fastball -- and flied out to center field.

"It worked out as good as it possibly could, we just didn't get the result," Lovullo said.

It's too soon to worry about the offense
Yes, the Padres no-hit the D-backs through six innings on Thursday and through seven on Friday, but Arizona made some hard contact on Friday.

In Thursday's game, only 29 percent of the balls that the D-backs put in play had an exit velocity of 95 mph or better, which is considered hard contact. They had a 48-percent hard-hit rate Friday night, but they couldn't get the key hit when they needed it.

"It was a grind for us," Lovullo said. "I thought we got to the very pivotal pitch in the at-bat, and then we just went out of the zone. We just didn't complete the at-bats offensively. I think we just came out of our plan and got too aggressive once we got to that really key point in the at-bat."