WEST PALM BEACH, Fla. -- For the first time in more than a decade, Jose Altuve won’t be starting at second base for the Astros on Opening Day.

The eight-time All-Star second baseman underwent surgery on his fractured right thumb on Wednesday, and his estimated timetable for resuming baseball activities is two months, according to Astros general manager Dana Brown. Altuve was struck by a pitch in Venezuela's loss to the United States in the World Baseball Classic on Saturday night, and a subsequent MRI and X-rays diagnosed the break.

Brown, however, said different players heal at different paces. The Astros are likely looking at a late-May, early-June return for Altuve, the team’s leadoff hitter.

“Some guys heal faster than other guys, and he seems to be one of those guys,” Brown said. “After that, we’ll assess and hopefully he’s coming along well. It looks like it’s going to be about two months.”

With Spring Training drawing to a close, Altuve is scheduled to remain in Houston; his Astros teammates will fly to Houston following the club's Spring Training game in West Palm Beach on Sunday.

Altuve exited during the fifth inning of Saturday's game when a 95.9 mph Daniel Bard fastball struck the second baseman on his right hand. Altuve said he knew right away the injury was severe. Phillies star Bryce Harper missed two months last year with a broken thumb, but each injury is different.

"Obviously, nobody wants to get hurt and start the season on the IL," Altuve said Sunday. "I want to control what I can control, and that's recover fast and get back to the team."

Altuve, entering his 13th season with the Astros, is coming off a terrific season in which he hit .300 with 28 homers, 57 RBIs, 18 stolen bases, 103 runs scored and a .920 OPS in 2022, helping the Astros win their second World Series title in six seasons. Altuve is a career .307/.362/.468 hitter and won American League Most Valuable Player honors in 2017.

“He’s one of the best players in the world, a leader for this team,” third baseman Alex Bregman said. “I’m super sorry for him. I think he came into Spring Training in great shape. He was playing great. In the WBC, he was on base all the time. I know he’ll come back stronger from it, and he’ll be ready to help us as soon as he gets back.”

The loss of Altuve not only leaves a hole at second base, but also at the top of the Astros’ batting order, where Altuve was a mainstay. He hit leadoff 137 times last year, with Jeremy Peña and Chas McCormick having the second-most leadoff starts (eight). Altuve’s loss reverberates through the entire lineup.

“We’ve got to put our heads together and find out what we can do and who we can do it with, and for an extended period of time,” Astros manager Dusty Baker said. “That’s a big loss. We have to come together as a unit and pick him up. I’ve lost some players in the past -- a few of this magnitude. I’ve got to put my thinking cap on.”

The Astros are likely going to turn to to utility players Mauricio Dubón and David Hensley, to cover Altuve while he’s out, but Brown hasn’t ruled out going outside the organization for help.

“I’m always in touch with all teams about acquiring players,” he said. “I’m always asking about what’s going on with other clubs, but now when you talk about it, it’s more of a reality with the injury to Altuve.

“We’re going to look internally first. We have a good, core group of guys here. No matter who we go out and get it’s going to be a lesser Jose Altuve because he’s such a great player. We’ll exhaust what we have here in the organization because we do have some good players and we’ve always been interested in depth, and sometimes to acquire that depth you have to go outside the organization.”

Dubón has 30 career starts at second, and Hensley has started at second 78 times in the Minor Leagues. Rylan Bannon, claimed off waivers from the Cubs in December, has 123 starts at second in the Minor Leagues. Non-roster invitee Dixon Machado is in the mix, as well.

Dubón went 2-for-3 with an RBI double and a run scored in the Astros' 5-2 win over the Mets on Wednesday, while Hensley also drove in a run and scored.

Altuve showed up to the Astros' facility Sunday morning, trying to manage a smile through his pain.

“We were having a great time, we were playing for our country and excited about it,” Altuve said. “I got hit and I’m going to miss some time, but you just focus on the recovery and get back to the field as soon as you can and go from there.”