SAN DIEGO -- Last month, the Giants staged an improbable comeback against All-Star closer Josh Hader at Oracle Park, mounting a six-run rally in the bottom of the ninth that was capped by Mike Yastrzemski’s walk-off grand slam. 

Hader now wears a different uniform after being traded from the Brewers to the Padres, but the Giants came close to pulling off another stunning rally against him on Tuesday night at Petco Park. 

The Giants scored three runs to tie the game in the top of the ninth, but their late comeback bid was halted by Manny Machado, who launched a three-run home run off Tyler Rogers to lift the Padres to a 7-4 walk-off win, evening this three-game series between the National League West rivals.

• Box score

The crushing loss snapped the Giants’ three-game winning streak and dropped them 6 1/2 games behind the Padres for the third National League Wild Card spot.

“I’m sick to my stomach, to be honest with you,” Rogers said. “The boys played a great game today. This one hurts. The way they battled back and played all game -- everybody played a good game except for me. It stinks.”

The Giants ultimately couldn’t contain the revamped Padres, who overhauled their roster by adding superstar Juan Soto, infielders Josh Bell and Brandon Drury, and Hader in a flurry of deals last week before the Trade Deadline.

“It’s as challenging of a 2-3-4 as there is,” manager Gabe Kapler said. “I think the best way to combat those two guys and maybe the middle of their lineup is by ensuring that they’re throwing a ton of strikes and getting ahead and staying ahead to the guys at the bottom of the lineup.

“[Jurickson] Profar is a good player, but you’ve got to get him out somehow, someway. You’ve got to get Austin Nola out somehow, someway, because you’re going to get hurt in a series like this by Machado and Soto.” 

Soto ignited San Diego’s offense on Tuesday, crushing a game-tying solo shot off Alex Cobb in the fourth inning for his first home run in a Padres uniform. Soto’s 395-foot drive to right field ended a 26-inning scoring drought for the Padres, though Yastrzemski managed to preserve the 1-1 tie by making a leaping catch at the center-field wall to rob Drury of a homer for the final out of the inning.

The Giants couldn’t get much going against Padres ace Joe Musgrove, who surrendered a first-inning solo homer to LaMonte Wade Jr., but little else over seven innings. But they showed late life when Hader took the mound in the ninth for his first save opportunity with San Diego.  

Yastrzemski walked, Wilmer Flores singled and Austin Slater reached on a hit-by-pitch to load the bases with no outs for Austin Wynns, who drew a walk to force in a run and cut the Padres’ lead to 4-2. That brought up J.D. Davis, who struck out looking despite taking two pitches from Hader that appeared to be off the plate. 

“I really felt bad for J.D. in that situation,” Cobb said. “He legitimately got the bat taken out of his hands.”

Another bases-loaded walk by Brandon Belt brought the Giants within one before Evan Longoria tied the game at 4 with a sacrifice fly to left field. Profar made a diving catch to prevent the Giants from adding on more runs, though Hader was still charged with a blown save and departed after throwing 37 pitches. 

The Padres subsequently brought in lefty Tim Hill to face Joc Pederson, who struck out to end the inning. The Giants had one more right-handed bat on the bench in Joey Bart, but Kapler said the rookie catcher was unavailable due to a right ankle issue.

Kapler was also trying to stay away from closer Camilo Doval, who had worked two days in a row, so he opted to bring in Rogers to pitch the bottom of the ninth. After a one-out single by Profar, Soto reached on catcher’s interference to put a pair of runners on for Machado, who promptly ended the game by sending a misplaced slider into the upper deck in left field. 

“When you miss down and in to Manny, he’s going to do it,” Rogers said. “We’ve got to come back and play a game [Wednesday] at 1 o’clock, so we’ll try and rinse this one off and get back to it.”