SAN DIEGO -- The Brewers were veering toward “not again” territory on Tuesday when news drifted around the clubhouse that slugging outfielder Hunter Renfroe was the latest to land on a crowded injured list. You could understand some sense of exasperation.

With shortstop Willy Adames and right-hander Freddy Peralta already on the IL and closer Josh Hader tending to a family matter back home, the Brewers found themselves without two of their three home run leaders, one of their three All-Star starting pitchers, plus an award-winning closer who is perfect in save chances this season. All within the past 10 days.

But baseball’s schedule doesn’t bend for teams facing staffing shortages, so the Brewers pieced together a 4-1 win over the Padres on Tuesday night at Petco Park, with reigning National League Cy Young Award winner Corbin Burnes appropriately playing the role of stopper, Tyrone Taylor taking Renfroe’s place in right field and powering a tie-breaking three-run home run and three relievers pitching one step closer to the end of the game than is typical -- Hoby Milner in the seventh to Trevor Gott in the eighth to Devin Williams in the ninth -- for a victory that halted San Diego’s five-game winning streak.

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Good teams persevere through trying circumstances, and the Brewers -- leaders of the NL Central -- fancy themselves a pretty good team.

“It just shows the depth that we got,” said Burnes. “We lost a tough one in extra innings [Monday] night but we bounced back and got a good one tonight. When someone goes down, we have other guys who can step up.”

Lately that mindset has been tested. Renfroe is expected to be down for two weeks or so with his strained hamstring. Adames is eligible to return from the IL beginning Tuesday, but will need at least through the weekend to test his sprained ankle, manager Craig Counsell said. Hader’s return is dependent on the well-being of his wife, who is experiencing a complicated pregnancy. And Peralta is not expected to pitch until later this season because of a shoulder injury.

Those injuries were on top of the losses of middle relievers Jandel Gustave and Jake Cousins (both on the IL) and J.C. Mejía, who was suspended.

“This is tough,” said Renfroe. “We have 19 games in 18 days, too. This is kind of a terrible time for it to happen.”

But, Renfroe added, “We’re going to keep battling. Get in the weight room, stay fit, still hit, still do all the things I can do to stay ready, and when I come off, be better than I was.”

On Tuesday, the Brewers were one win better after Burnes allowed his first run all year before the third inning but kept it at 1-0 Padres until Mike Brosseau slugged a tying home run in the fifth inning and Taylor greeted reliever Craig Stammen with a go-ahead home run for a 4-1 lead in the sixth.

It was a timely contribution for Taylor, who, with Andrew McCutchen, could prove the players most impacted by Renfroe’s absence. McCutchen figures to see more time in the outfield in addition to his duty at designated hitter, Counsell said. And Taylor, who has started games at all three outfield spots this season, has the tool set most comparable to Renfroe in right.

“I already show up here every day expecting to play even though I knew what my role was,” Taylor said. “I’m just looking forward to going out there with the guys and having some fun playing ball.”

Without Hader and setup man Brad Boxberger (after he threw 28 pitches the night before), the Brewers turned to others to preserve that lead. It ended with Milner making the game’s signature defensive play for the first two outs of the seventh, then Gott striking out Wil Myers to end the eighth when Myers represented the tying run and Williams logging his third save.

“There’s going to be situations like that throughout the season for everybody,” Milner said, “and the teams that win those games are the teams that end up in the playoffs.”

Playoff teams also have pitchers like Burnes, who induced just two whiffs on his cutter but was excellent as usual, allowing only the first-inning run on five hits in six innings. It was Milwaukee’s 15th start this season of at least six innings with one or no runs -- most in the Majors.

Burnes getting through the sixth allowed Counsell to piece together the rest.

“Injuries are bad no matter where they come from, and when they impact your guys that are regulars in your lineup or your rotation, there’s going to be a cascading effect,” Counsell said earlier in the day. “Unfortunately, we’ve lost some really good players the last couple of days or weeks and we’ve just got to withstand that as a group. Every day, hopefully, guys are getting better and getting closer to playing again. That’s how you’ve got to see it.”