LOS ANGELES -- Anthony DeSclafani has been one of the most dominant pitchers in the Majors in June, but he couldn’t end the month on a high note after struggling to solve a familiar nemesis: the Dodgers.

DeSclafani surrendered a season-high three home runs over five innings as the Giants were outslugged, 3-2, in Monday night’s series opener at Dodger Stadium.

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The National League West rivals combined for five solo home runs, with Mookie Betts, Max Muncy and Will Smith belting shots for Los Angeles, and LaMonte Wade Jr. and Brandon Crawford going deep for San Francisco. The Giants outhit the Dodgers, 11-5, but they couldn’t capitalize on multiple scoring opportunities, finishing 0-for-13 with runners in scoring position and leaving 11 men on base.

“The three home runs obviously ended up being the difference-maker,” DeSclafani said. “I gave up three, and Trevor [Bauer] gave up two. That’s really all it was.”

The division-leading Giants have now lost back-to-back games for the first time since being swept at home by the Dodgers from May 21-23, allowing Los Angeles to pull within 2 1/2 games of first place in the NL West. The defeat was compounded by the loss of right fielder Mike Yastrzemski, who was removed from the game after fouling a ball off his right shin in his final at-bat in the seventh inning. X-rays came back negative for Yastrzemski, who is considered day to day with a lower right leg contusion.

DeSclafani entered Monday 4-0 with a 1.00 ERA over his first four starts in June, but he received a rude welcome at Chavez Ravine when Betts and Muncy crushed back-to-back home runs to sink the Giants into a 2-0 hole in the first inning. Both blasts came on misplaced fastballs from DeSclafani, who hadn’t allowed multiple home runs in any of his first 15 starts for San Francisco this year.

Wade brought the Giants within one with a towering leadoff shot off Bauer in the third, but Smith clipped DeSclafani for another homer in the following inning to extend Los Angeles’ lead to 3-1. It was another poorly located pitch from DeSclafani, who hung a 1-2 slider that Smith walloped out to left-center field. DeSclafani departed after allowing only five hits, but three ended up leaving the yard, lifting his ERA to 2.91 on the season.

“It’s definitely unfortunate that three of the five were home runs, two of them coming on two-strike counts,” DeSclafani said. “I’ve got to do a better job of making better pitches in those counts.”

DeSclafani is now 0-3 with a 10.95 ERA in three starts against the Dodgers this year, though the numbers are skewed by a clunker on May 23, when he allowed a career-high 10 runs over 2 2/3 innings at Oracle Park. Outside of his three defeats against Los Angeles, DeSclafani is 8-1 with a 1.68 ERA in 13 outings for the Giants.

“They’re definitely aggressive against me, no question,” DeSclafani said of the Dodgers. “That can either go for me or against me. They obviously put three really good swings on the ball, and it ended up going against me today. But if you make good pitches, it can also lead to really quick outs. It obviously sucks giving up three home runs, but at the end of the day, it’s three runs. No matter how I gave them up, I felt like I kept the team in the game, and we were in it until the last inning.”

DeSclafani’s pitch count stood at 86 after five innings, but manager Gabe Kapler opted to send Darin Ruf to pinch-hit for him after the Giants tested Bauer in the sixth. Crawford opened the inning with his team-high 17th home run of the season -- a 444-foot shot to straightaway center field that ranked as his longest homer since Statcast began tracking in 2015 -- and Wilmer Flores followed with a double to put the tying run in scoring position with no outs.

Still, Bauer managed to avoid further damage by retiring Steven Duggar, Donovan Solano and Ruf to end the inning.

Mike Tauchman, who entered the game to replace Yastrzemski in right field in the bottom of the seventh, came close to igniting a last-ditch rally against Dodgers closer Kenley Jansen in the ninth, but he was thrown out at second base after trying to stretch a single into a double. The Giants challenged the call, but the ruling was upheld following a replay review. Kapler said he rewatched the play on video and felt that Tauchman was safe.

“I felt like initially I avoided the tag enough to get my hand in there,” Tauchman said. “Whether or not I came off, it’s tough. It’s frustrating. That’s the call they made. That’s kind of just the way it goes, I guess. It was a really close play.”