Astros Roster & Staff
Transactions
| Date | Transaction |
| 07/30/22 | Houston Astros signed C John Garcia. |
| 07/28/22 | Houston Astros signed RHP Andrew Taylor. |
| 07/28/22 | Houston Astros signed RHP Logan VanWey. |
| 07/28/22 | Houston Astros signed RHP Austin Temple. |
| 07/28/22 | Houston Astros signed SS Tommy Sacco Jr.. |
| 07/28/22 | Houston Astros signed 1B Garrett McGowan. |
| 07/28/22 | Houston Astros signed C Ryan Wrobleski. |
| 07/28/22 | Houston Astros signed SS Zach Dezenzo. |
| 07/28/22 | Houston Astros signed OF Ryan Clifford. |
| 07/28/22 | Houston Astros signed RHP Joey Mancini. |
| 07/28/22 | Houston Astros signed SS Tim Borden II. |
| 07/27/22 | Houston Astros sent RHP Lance McCullers Jr. on a rehab assignment to Sugar Land Space Cowboys. |
| 07/26/22 | Houston Astros signed OF Jacob Melton. |
| 07/26/22 | Houston Astros signed RHP Brett Gillis. |
| 07/26/22 | Houston Astros signed OF Drew Gilbert. |
| 07/24/22 | Houston Astros activated RHP Ryan Pressly from the paternity list. |
| 07/24/22 | Houston Astros optioned LHP Parker Mushinski to Sugar Land Space Cowboys. |
| 07/23/22 | Houston Astros signed LHP Trey Dombroski. |
| 07/22/22 | Houston Astros signed RHP Tyler Guilfoil. |
| 07/22/22 | Houston Astros signed OF Zach Cole Jr.. |
| 07/22/22 | Houston Astros sent RHP Lance McCullers Jr. on a rehab assignment to Corpus Christi Hooks. |
| 07/22/22 | Houston Astros signed C Collin Price. |
| 07/22/22 | Houston Astros signed RHP Michael Knorr. |
| 07/22/22 | Houston Astros signed RHP Nolan DeVos. |
| 07/22/22 | Houston Astros signed RHP A.J. Blubaugh. |
| 07/22/22 | Houston Astros signed SS Jackson Loftin. |
| 07/22/22 | Houston Astros optioned RHP Brandon Bielak to Sugar Land Space Cowboys. |
| 07/21/22 | Houston Astros activated LHP Parker Mushinski. |
| 07/21/22 | Houston Astros activated 1B Yordan Alvarez from the reserve list. |
| 07/21/22 | Houston Astros signed free agent RHP Angel Aybar to a minor league contract. |
| 07/21/22 | Houston Astros placed RHP Ryan Pressly on the paternity list. |
| 07/21/22 | Houston Astros optioned CF Jose Siri to Sugar Land Space Cowboys. |
| 07/21/22 | Houston Astros recalled RHP Brandon Bielak from Sugar Land Space Cowboys. |
| 07/19/22 | Houston Astros signed free agent LHP Fernando Silvera to a minor league contract. |
| 07/14/22 | Houston Astros signed free agent SS Luis Colon to a minor league contract. |
| 07/11/22 | Houston Astros signed free agent RHP Jose Varela to a minor league contract. |
| 07/10/22 | Houston Astros placed 1B Yordan Alvarez on the 10-day injured list. Right hand inflammation. |
| 07/10/22 | Houston Astros recalled CF Jose Siri from Sugar Land Space Cowboys. |
| 07/06/22 | Houston Astros sent LHP Parker Mushinski on a rehab assignment to Sugar Land Space Cowboys. |
| 07/06/22 | Houston Astros sent LHP Parker Mushinski on a rehab assignment to Sugar Land Space Cowboys. |
| 07/05/22 | Houston Astros signed free agent C Victor Diaz to a minor league contract. |
| 07/04/22 | Houston Astros activated RHP Jake Odorizzi. |
| 07/04/22 | Houston Astros optioned RHP Enoli Paredes to Sugar Land Space Cowboys. |
| 07/01/22 | Houston Astros transferred LHP Blake Taylor from the 15-day injured list to the 60-day injured list. Left elbow discomfort. |
| 07/01/22 | Houston Astros placed C Jason Castro on the 10-day injured list. Left knee discomfort. |
| 07/01/22 | Houston Astros selected the contract of C Korey Lee from Sugar Land Space Cowboys. |